Understanding Genomic and Hereditary Cancer Risk

Understanding Genomic and Hereditary Cancer Risk

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  • Author: Suzanne M. Mahon
  • Publisher:
  • ISBN: 9781635930504
  • Category :
  • Languages : en
  • Pages :

"Collecting a family medical history is a regular component of the nursing assessment process that often includes information on familial cancer diagnoses, and patients may fear that they or their loved ones might be at increased risk for developing cancer because of hereditary factors. Although true inherited risk for developing cancer is much less common than acquired risk for developing cancer, approximately 10% of cancer diagnoses can be attributed to inherited risk. The identification of families exhibiting hereditary cancer syndromes enables individuals at risk to engage in increased surveillance and, in some cases, risk-reducing surgery and other preventive measures, which ultimately lead to decreasing the morbidity and mortality associated with a cancer diagnosis. The role of the nurse in helping patients to understand and manage hereditary cancer risk requires specialized knowledge of genetics and genomics concepts. Understanding Genomic and Hereditary Cancer Risk: A Handbook for Oncology Nurses provides background on basic genetic and genomic concepts, particularly those related to hereditary risk for developing cancer, to aid nurses in knowing when and why to refer patients. It also provides reliable information about how and why genetic and genomic testing can both aid in treatment decisions and also guide recommendations for cancer prevention and early detection. The nurse's role in genetic testing and counseling are discussed, as are questions and answers about types of testing, including direct-to-consumer genetic testing. Following genetic testing, most genetics professionals provide detailed information about recommendations for care, including recommendations for ongoing prevention and early detection. For patients who are found to have a harmful mutation, these recommendations can be extensive and are based on the personal and family medical history, as well as the specific variant. This book provides quick overviews of many of the more common hereditary variants as well as resources for more information. This handbook provides nurses with the essentials to understand genomic and hereditary cancer risk, to assist in facilitating interprofessional care with genetics and other oncology professionals, and to provide their patients with accurate and reassuring information"--


Inherited Cancer Syndromes

Inherited Cancer Syndromes

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  • Author: C. Neal Ellis
  • Publisher: Springer Science & Business Media
  • ISBN: 0387402462
  • Category : Medical
  • Languages : en
  • Pages : 263

Provides the clinician with a valuable tool for all aspects of patient care in inherited cancer syndromes, which may amount to up to 10% of all cancers. It presents the fundamental principles of assessing the genetic risk of cancer, the role of genetic counseling, ethical issues in genetic testing for cancer susceptibility, medical-legal issues, and clinical management principles.


Inherited Cancer Syndromes

Inherited Cancer Syndromes

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  • Author: C. Neal Ellis
  • Publisher: Springer Science & Business Media
  • ISBN: 1441968210
  • Category : Medical
  • Languages : en
  • Pages : 208

The second edition of Inherited Cancer Syndromes incorporates new genetic markers data with the clinical utility and practicality of the first edition.


Concise Handbook of Familial Cancer Susceptibility Syndromes

Concise Handbook of Familial Cancer Susceptibility Syndromes

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  • Author:
  • Publisher:
  • ISBN: 9780199558391
  • Category : Cancer
  • Languages : en
  • Pages : 93


A Guide to Cancer Genetics in Clinical Practice

A Guide to Cancer Genetics in Clinical Practice

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  • Author: Sue Clark,
  • Publisher: tfm Publishing Limited
  • ISBN: 1908986336
  • Category : Medical
  • Languages : en
  • Pages : 257

FIRST PRIZE Winner in the Oncology category of the 2010 BMA Medical Book Competition. Intensive research over the last fifteen years has yielded a vast expansion in our understanding of the role of inheritance and genetics in a variety of cancers. Several inherited conditions have been identified which result in a high risk of various cancers; some of these were previously recognized, but the genetic basis underlying them has now been elucidated. This knowledge is now entering the sphere of routine clinical care. Surgeons, gastroenterologists, gynaecologists, oncologists, endocrinologists and many others need an awareness of these disorders, an understanding of genetic testing and when it is indicated, and how to manage patients with inherited cancer predisposition and their families. This book covers the basic concepts of cancer genetics. The common inherited cancer syndromes are each dealt with in greater depth, with the current management outlined. This book is aimed at all clinicians who may encounter these conditions in their practice. It aims to facilitate identification of high-risk individuals and families, to inform interaction with geneticists and other subspecialists, to provide a basis for patient management and to stimulate interest in these fascinating conditions.


Genetics of Colorectal Cancer

Genetics of Colorectal Cancer

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  • Author: John D. Potter
  • Publisher: Springer
  • ISBN: 9780387095677
  • Category : Medical
  • Languages : en
  • Pages : 309

Genetic susceptibility refers to how variations in a person’s genes increase or decrease his or her susceptibility to environmental factors, such as chemicals, radiation and lifestyle (diet and smoking). This volume will explore the latest findings in the area of genetic susceptibility to gastrointestinal cancers, focusing on molecular epidemiology, DNA repair, and gene-environment interactions to identify factors that affect the incidence of GI cancers. Topics will include germline susceptibility, including Mendelian patterns of inheritance and gene-environment interactions that lead to cancer etiology.


A Cancer in the Family

A Cancer in the Family

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  • Author: Theodora Ross, MD, PhD
  • Publisher: Penguin
  • ISBN: 0147516900
  • Category : Health & Fitness
  • Languages : en
  • Pages : 306

A Kirkus Best Book of 2016 Oncologist and cancer gene hunter Theo Ross delivers the first authoritative, go-to for people facing a genetic predisposition for cancer There are 13 million people with cancer in the United States, and it’s estimated that about 1.3 million of these cases are hereditary. Yet despite advanced training in cancer genetics and years of practicing medicine, Dr. Theo Ross was never certain whether the history of cancers in her family was simple bad luck or a sign that they were carriers of a cancer-causing genetic mutation. Then she was diagnosed with melanoma, and for someone with a dark complexion, melanoma made no sense. It turned out there was a genetic factor at work. Using her own family’s story, the latest science of cancer genetics, and her experience as a practicing physician, Ross shows readers how to spot the patterns of inherited cancer, how to get tested for cancer-causing genes, and what to do if you have one. With a foreword by Siddartha Mukherjee, prize winning author of The Emperor of All Maladies, this will be the first authoritative, go-to for people facing inherited cancer, this book empowers readers to face their genetic heritage without fear and to make decisions that will keep them and their families healthy.


Practical Gynecologic Pathology

Practical Gynecologic Pathology

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  • Author: Jian-Jun Wei
  • Publisher: Springer Nature
  • ISBN: 3030686086
  • Category : Medical
  • Languages : en
  • Pages : 442

This book serves as a quick review or summary of major diagnostic challenges in gynecologic pathology and embraces a Q/A format by providing the desired diagnostic knowledge. It combines the diagnostic approach as it relates to morphology and the relevant ancillary tests which impact on clinical outcome or management. Each topic is written by subspecialty gynecological pathologists in the field in making this a valuable book for a broad spectrum of readers, particularly pathology trainees, junior pathologists and general practicing pathologists. These authors provide concise and accurate answers for a variety of common, yet challenging diagnostic scenarios that are relevant and frequently encountered in daily practice. The book walks readers through current topics, controversies and diagnostic dilemmas for common gynecologic diseases with morphologic features and key ancillary tests, richly illustrated with figures and tables. To reflex the current advances in diagnostic gynecological pathology, the topics are closely correlated with the updated disease classifications and diagnostic criteria, particularly those recognized by the World Health Organization. Practical Gynecologic Pathology provides a concise summary and review for some of the most difficult, prevailing and emerging concepts in gynecologic pathology.


Principles of Clinical Cancer Genetics

Principles of Clinical Cancer Genetics

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  • Author: Daniel C. Chung
  • Publisher: Springer Science & Business Media
  • ISBN: 038793846X
  • Category : Medical
  • Languages : en
  • Pages : 234

Advances in genetics are transforming estimates of an individual’s risk of developing cancer and approaches to prevention and management of cancer in those who may have increased susceptibility. Identifying and caring for patients with hereditary cancer syndromes and their family members present a complex clinical, scientific and social challenge. This textbook, by leading experts at Massachusetts General Hospital Cancer Center, highlights the current understanding of the genetics of hereditary cancers of the breast, ovary, colorectum, stomach, pancreas, kidney, skin, and endocrine organs. Practical guidelines for the use of genetic testing, cancer screening and surveillance, prophylactic surgery, and promising targeted therapeutic agents are discussed. In addition, ongoing research involving genome-wide screens to identify novel modest risk-associated genetic loci are explored, along with new approaches to the application of genetic markers in guiding therapeutic options.


Clinical Gynecology

Clinical Gynecology

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  • Author: Eric J. Bieber
  • Publisher: Cambridge University Press
  • ISBN: 1107040396
  • Category : Medical
  • Languages : en
  • Pages : 1127

Written with the busy practice in mind, this book delivers clinically focused, evidence-based gynecology guidance in a quick-reference format. It explores etiology, screening, tests, diagnosis, and treatment for a full range of gynecologic health issues. The coverage includes the full range of gynecologic malignancies, reproductive endocrinology and infertility, infectious diseases, urogynecologic problems, gynecologic concerns in children and adolescents, and surgical interventions including minimally invasive surgical procedures. Information is easy to find and absorb owing to the extensive use of full-color diagrams, algorithms, and illustrations. The new edition has been expanded to include aspects of gynecology important in international and resource-poor settings.