Lymphocyte Trafficking in Health and Disease

Lymphocyte Trafficking in Health and Disease

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  • Author: Raffaele Badolato
  • Publisher: Springer Science & Business Media
  • ISBN: 376437442X
  • Category : Medical
  • Languages : en
  • Pages : 249

This book deals with the description of the role of chemokines in immune response and underlines potential targets of therapeutical intervention. It offers a series of international contributions of the most challenging aspects of lymphocyte migration in homeostasis and in disease, and has a special focus on diseases and targets of therapeutical intervention. The book will interest researchers and clinicians from inflammation research.


Molecular Biology of the Cell

Molecular Biology of the Cell

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  • Author:
  • Publisher:
  • ISBN: 9780815332183
  • Category : Cells
  • Languages : en
  • Pages : 0


Tertiary Lymphoid Organs (TLOs): Powerhouses of Disease Immunity

Tertiary Lymphoid Organs (TLOs): Powerhouses of Disease Immunity

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  • Author: Changjun Yin
  • Publisher: Frontiers Media SA
  • ISBN: 2889451801
  • Category :
  • Languages : en
  • Pages : 237

The immune system employs TLOs to elicit highly localized and forceful responses to unresolvable peripheral tissue inflammation. Current data indicate that TLOs are protective but they may also lead to collateral tissue injury and serve as nesting places to generate autoreactive lymphocytes. A better comprehension of these powerhouses of disease immunity will likely facilitate development to unprecedented and specific therapies to fight chronic inflammatory diseases.


In Vivo Models of Inflammation

In Vivo Models of Inflammation

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  • Author: Christopher S. Stevenson
  • Publisher: Springer Science & Business Media
  • ISBN: 3764375205
  • Category : Medical
  • Languages : en
  • Pages : 216

In Vivo Models of Inflammation (Vol. 1) provides biomedical researchers in both the pharmaceutical industry and academia with a description of the state-of-the-art animal model systems used to emulate diseases with components of inflammation. This second edition acts as a complement to the first, describing and updating the standard models that are most utilized for specific disease areas. New models are included exploring emerging areas of inflammation research.


Leukocyte Trafficking

Leukocyte Trafficking

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  • Author: Alf Hamann
  • Publisher: John Wiley & Sons
  • ISBN: 3527607013
  • Category : Medical
  • Languages : en
  • Pages : 557

Written by known specialists in the field, this is a comprehensive and timely overview of a central and expanding topic. Simultaneously an introduction and a description of the latest concepts, findings and methods, the handbook provides basic knowledge on technical issues required for those intending to research in the field. It covers the functional role of involved molecules and the cellular mechanisms, and addresses selected examples for their possible application in therapy -- bridging the gap between trafficking mechanisms and novel therapeutic strategies. In addition, it includes selection of proven and timesaving methods for studying cell trafficking in vitro and in vivo. The accompanying CD-ROM makes leukocyte migration videos available to a broad audience for the first time.


Lymphocyte Trafficking in Health and Disease

Lymphocyte Trafficking in Health and Disease

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  • Author: Raffaele Badolato
  • Publisher: Birkhäuser
  • ISBN: 9783764373085
  • Category : Medical
  • Languages : en
  • Pages : 253

This book deals with the description of the role of chemokines in immune response and underlines potential targets of therapeutical intervention. It offers a series of international contributions of the most challenging aspects of lymphocyte migration in homeostasis and in disease, and has a special focus on diseases and targets of therapeutical intervention. The book will interest researchers and clinicians from inflammation research.


Lymphocyte Trafficking in Health and Disease

Lymphocyte Trafficking in Health and Disease

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  • Author: Raffaele Badolato
  • Publisher: Birkhäuser
  • ISBN: 9783764390853
  • Category : Medical
  • Languages : en
  • Pages : 253

This book deals with the description of the role of chemokines in immune response and underlines potential targets of therapeutical intervention. It offers a series of international contributions of the most challenging aspects of lymphocyte migration in homeostasis and in disease, and has a special focus on diseases and targets of therapeutical intervention. The book will interest researchers and clinicians from inflammation research.


Handbook of Human Stress and Immunity

Handbook of Human Stress and Immunity

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  • Author: Ronald Glaser
  • Publisher: Academic Press
  • ISBN: 1483295125
  • Category : Medical
  • Languages : en
  • Pages : 436

In 1964, George Solomon coined the term psychoneuroimmunology. In the intervening 30 years, this term has emerged into a dynamic field of study which investigates the unique interactions between the nervous, endocrine, and immune systems. The Handbook of Human Stress and Immunity is a comprehensive reference for this dynamic new field. Focusing on how stressors impact the central nervous system and the resulting changes in immune responses, the Handbook is the first to describehow stress specifically affects human immune systems. It discusses how stress generally makes people more susceptible to infection, how personal support systems can counteract the physiological effects of stress, and how stress, or lack of stress, affects the aging process. Chapters are authored by the leading names in the field and cover such diseases as autoimmune disease, viral pathogenesis, herpes, HIV, and AIDS.


The Peripheral T-Cell Lymphomas

The Peripheral T-Cell Lymphomas

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  • Author: Owen A. O'Connor
  • Publisher: John Wiley & Sons
  • ISBN: 1119671310
  • Category : Medical
  • Languages : en
  • Pages : 434

THE PERIPHERAL T-CELL LYMPHOMAS Provides a comprehensive look at Peripheral T-Cell lymphomas, including the group’s unique geographic distribution, underlying genetics, and novel treatments Peripheral T-Cell lymphomas (PTCL) are a diverse group of lymphoid malignancies that develop from mature T cells and natural killer (NK) cells. PTCL represent 10-15% of all cases of non-Hodgkin lymphoma in the US, and up to 20-25% of cases in South America, Asia, and other regions around the world. The role of different etiologic factors and the variation of geographic distribution makes PTCL one of the most difficult types of cancer to understand and treat. For the first time in a single volume, The Peripheral T-Cell Lymphomas presents a comprehensive survey of this complex and rare group of blood cancers. Featuring contributions from an international team of leading authorities in the various aspects of PTCL, this authoritative text covers biology, epidemiology, classification, approved and emerging drugs, molecular genetics, and more. Detailed clinical chapters address diagnosis, prognosis, and treatment of each of the major PTCL subtypes identified in the 2018 WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues. This much-needed resource: Covers the biological basis, epidemiology, classification, and treatment of PTCL Discusses the future of the field, including global collaboration efforts and novel approaches to PCTL Explores the role of biologics in PTCL and autologous and allogeneic stem-cell transplantation Offers new insights on molecular pathogenesis, innovative therapeutics, and novel drug combinations Features contributions from the Chairs The T-Cell Lymphoma Forum: the world’s largest meeting focused on PTCL Reflecting the unique epidemiology and genetic diversity of the PTCL, The Peripheral T-Cell Lymphomas is an indispensable source of data, insight, and references for the medical community, particularly oncologists and hematologists in both training and practice.


Arrest chemokines

Arrest chemokines

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  • Author: Klaus Ley
  • Publisher: Frontiers Media SA
  • ISBN: 2889194302
  • Category : Chemokines
  • Languages : en
  • Pages : 109

Arrest chemokines are a small group of chemokines that promote leukocyte arrest from rolling by triggering rapid integrin activation. Arrest chemokines have been described for neutrophils, monocytes, eosinophils, naïve lymphocytes and effector memory T cells. Most arrest chemokines are immobilized on the endothelial surface by binding to heparin sulfate proteoglycans. Whether soluble chemokines can promote integrin activation and arrest is controversial (Alon-Gerszten). Many aspects of the signaling pathway from the GPCR chemokine receptor to integrin activation are the subject of active investigation. Leukocyte adhesion deficiency III is a human disease in which chemokine-triggered integrin activation is defective because of a mutation in the cytoskeletal protein kindlin-3. About 10 different such mutations have been described. The defects seen in patients with LAD-III elucidate the importance of rapid integrin activation for host defense in humans. We welcome reports that help clarifying this crucial first step in the process of leukocyte transendothelial migration.