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The orbitofronal cortex plays a critical role in emotion, learning, and behavioural flexibility. This volume provides a reference for established clinicians and researchers as well as trainees in neurology, neurosurgery, psychiatry, psychology, and neuroscience.--[Source inconnue].
'The Orbitofrontal Cortex' explores a part of the brain that is important in human emotion, pleasure, decision-making, valuation, and personality. In ten chapters the book describes: · The OFC's connections; · Its neuron level neurophysiology which is essential for understanding what information is represented in the orbitofrontal cortex; · Functional neuroimaging of the orbitofrontal cortex; · How it relates to the previous and succeeding areas in brain processing; · The effects of damage to the orbitofrontal cortex which provides important evidence about its functions; · How the orbitofrontal cortex is involved in psychiatric disorders including depression, bipolar disorder, and autism; · How and what the orbitofrontal cortex computes; · Future directions in understanding the functions of the orbitofrontal cortex in health and disease. The book is unique in providing a coherent multidisciplinary approach to understanding the functions of one of the most interesting regions of the human brain, in both health and in disease, including depression The Orbitofrontal Cortex will be valuable for those in the fields of neuroscience, neurology, psychology, psychiatry, biology, animal behaviour, economics, and philosophy, from the undergraduate level upwards.
The prefrontal cortex reaches its greatest development in the human brain, making up nearly one third of the neocortex. Due to its remarkable evolution, the prefrontal cortex plays an important role in higher integrative functions such as information processing, thinking, understanding, attention, behavior, motivation, emotions, working memory, and analysis. This book brings together theoretical and technical research advances on the prefrontal cortex, from the basic explanations of the neuronal architecture of the prefrontal cortex and its anatomy, presenting it as a morphological substrate for many psychological conditions, through normal and altered connectivity and its manifestation in different behavior and identification of organizational levels inside the prefrontal cortex through different neuroimaging methods. It also provides an interdisciplinary view of the prefrontal cortex and its issues and discovers the main role of this part of brain in psychosocial, economic, and cultural adaptation.
The Prefrontal Cortex, Fifth Edition, provides users with a thoroughly updated version of this comprehensive work that has historically served as the classic reference on this part of the brain. The book offers a unifying, interdisciplinary perspective that is lacking in other volumes written about the frontal lobes, and is, once again, written by the award-winning author who discovered "memory cells," the physiological substrate of working memory. The fifth edition constitutes a comprehensive update, including all the major advances made on the physiology and cognitive neuroscience of the region since publication in 2008. All chapters have been fully revised, and the overview of prefrontal functions now interprets experimental data within the theoretical framework of the new paradigm of cortical structure and dynamics (the Cognit Paradigm), addressing the accompanying social, economic, and cultural implications. Provides a distinctly interdisciplinary view of the prefrontal cortex, covering all major methodologies, from comparative anatomy to modern imaging Unique analysis and synthesis of a large body of basic and clinical data on the subject (more than 2000 references) Written by an award-winning author who discovered "memory cells," the physiological substrate of working memory Synthesizes evidence that the prefrontal cortex constitutes a complex pre-adaptive system Incorporates emerging study of the role of the frontal lobes in social, economic, and cultural adaptation
The past ten years have witnessed intense research on the function of orbitofrontal cortex. As a result, the orbitofrontal cortex has been assigned roles in a number of human behaviors and emotions, from tasks such as assessing economic value and making decisions to the emotional states of regret and uncertainty. Orbitofrontal dysfunction has also been implicated in a variety of human disease states, including addiction, depression and bipolar, obsessive-compulsive, and attention deficit disorders. Despite an enormous increase in our knowledge about this region, we still do not have an account of the contributions that the orbitofrontal cortex makes across different circuits to support human behavior, nor do we understand how changes in this structure or its connectivity may contribute to disease states. This volume explores areas of research that are critical to move the field beyond a circuit-centric view of the orbitofrontal cortex to define the roles this area plays in human behavior and mental health.
'The Orbitofrontal Cortex' explores a part of the brain that is important in human emotion, pleasure, decision-making, valuation, and personality. The book is unique in providing a coherent multidisciplinary approach to understanding the functions of one of the most interesting regions of the human brain, in both health and in disease.
Thanks to a resurgence of interest and a recent proliferation of research techniques, much new and illuminating data has emerged during the last decade relating to the prefrontal cortex, particularly in primates and rodents. In view of this progress, the 16th International Summer School of Brain Research was held in Amsterdam, The Netherlands from 28 August to 1 September 1989, devoted to the topic of `The Prefrontal Cortex: Its Structure, Function and Pathology'. The edited proceedings, embodied in this 85th volume of `Progress in Brain Research', fall into three sections - the first of which, following two introductory chapters, discusses the present knowledge of the organization of prefrontal cortical systems. In the second section, developmental and plasticity aspects in rodent and human cortex are considered, whilst the third section deals extensively with the functional aspects characteristic for the prefrontal cortex in primates, rats and rabbits. The last section reviews several topics on dysfunction of prefrontal cortex in rat and man, including a historical review on psychosurgery.
The prefrontal cortex makes up almost a quarter of the human brain. The Neurobiology of the Prefrontal Cortex presents a new theory about its fundamental function. Written by two leading brain scientists, it is an important contribution to our understanding of the evolution and functioning of the human brain.
