This book provides the latest updates on the major challenges of bridging large bone defects, where options range from autografts, “tissue engineered bone”, biomaterials (hydroxyapatite, polycaprolactone and third generation biomaterials) to prostheses. Emphasis has been made on bone tissue engineering, the current state-of-the-art in this field, problems encountered with cell culture technology, scaffolds and bone growth factors (including genomics) and the use of gene therapy for the application of bone growth factors. Attention has also been given to the use of bone autografts. It also covers the use of biomaterials and prostheses as other options for reconstruction. Clinical applications, in addition to the basic science, are also included throughout the discussions. Contents:Basic Science of BoneAutograftsAllograftsGenomicsBone Tissue EngineeringGrowth FactorsCeramicsProstheses Readership: Undergraduate students, graduate students, researchers and lecturers in bone tissue engineering, bone growth factors, biomaterials, autografts, allografts, prostheses, as well as orthopaedic surgeons, plastic and reconstructive surgeons, maxillo-facial surgeons and tissue bank operators. Keywords:Bone Grafts;Bone Substitutes;Basic Science;Clinical Applications;Bone Tissue Engineering;Bone Growth Factor;Genomics;Bone Gene Therapy;BiomaterialsKey Features:Latest updates on the major challenges of bridging large bone defects, including state-of-the-art optionsClinical applications highlighted