Next-Generation Genome Sequencing

2011-08-24

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Author: Michal Janitz
Publisher: John Wiley & Sons
ISBN: 3527644733
Category : Science
Languages : en
Pages : 281

Written by leading experts from industry and academia, this first single comprehensive resource addresses recent developments in next generation DNA sequencing technology and their impact on genome research, drug discovery and health care. As such, it presents a detailed comparative analysis of commercially available platforms as well as insights into alternative, emerging sequencing techniques. In addition, the book not only covers the principles of DNA sequencing techniques but also social, ethical and commercial aspects, the concept of personalized medicine and a five-year perspective of DNA sequencing.

Clinical Genome Sequencing

2019-04-03

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Author: Aad Tibben
Publisher: Academic Press
ISBN: 9780128133354
Category : Medical
Languages : en
Pages : 0

Clinical Genome Sequencing: Psychological Aspects thoroughly details key psychological factors to consider while implementing genome sequencing in clinical practice, taking into account the subtleties of genetic risk assessment, patient consent and best practices for sharing genomic findings. Chapter contributions from leading international researchers and practitioners cover topics ranging from the current state of genomic testing, to patient consent, patient responses to sequencing data, common uncertainties, direct-to-consumer genomics, the role of genome sequencing in precision medicine, genetic counseling and genome sequencing, genome sequencing in pediatrics, genome sequencing in prenatal testing, and ethical issues in genome sequencing. Applied clinical case studies support concept illustration, making this an invaluable, practical reference for this important and multifaceted topic area within genomic medicine.

Genome Sequencing Technology and Algorithms

2008

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Author: Sun Kim
Publisher: Artech House Publishers
ISBN:
Category : Computers
Languages : en
Pages : 288

The 2003 completion of the Human Genome Project was just one step in the evolution of DNA sequencing. This trailblazing work gives researchers unparalleled access to state-of-the-art DNA sequencing technologies, new algorithmic sequence assembly techniques, and emerging methods for both resequencing and genome analysis.

Mapping and Sequencing the Human Genome

1988-01-01

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Author: National Research Council
Publisher: National Academies Press
ISBN: 0309038405
Category : Science
Languages : en
Pages : 128

There is growing enthusiasm in the scientific community about the prospect of mapping and sequencing the human genome, a monumental project that will have far-reaching consequences for medicine, biology, technology, and other fields. But how will such an effort be organized and funded? How will we develop the new technologies that are needed? What new legal, social, and ethical questions will be raised? Mapping and Sequencing the Human Genome is a blueprint for this proposed project. The authors offer a highly readable explanation of the technical aspects of genetic mapping and sequencing, and they recommend specific interim and long-range research goals, organizational strategies, and funding levels. They also outline some of the legal and social questions that might arise and urge their early consideration by policymakers.

The Yeast Two-hybrid System

1997

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Author: Paul L. Bartel
Publisher: Oxford University Press, USA
ISBN: 9780195109382
Category : Carrier proteins
Languages : en
Pages : 362

This volume, part of the Advances in Molecular Biology series, presents work by pioneers in the field and is the first publication devoted solely to the yeast two-hybrid system. It includes detailed protocols, practical advice on troubleshooting, and suggestions for future development. In addition, it illustrates how to construct an activation domain hybrid library, how to identify mutations that disrupt an interaction, and how to use the system in mammalian cells. Many of the contributors have developed new applications and variations of the technique.

Sequence — Evolution — Function

2013-06-29

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Author: Eugene V. Koonin
Publisher: Springer Science & Business Media
ISBN: 1475737831
Category : Science
Languages : en
Pages : 482

Sequence - Evolution - Function is an introduction to the computational approaches that play a critical role in the emerging new branch of biology known as functional genomics. The book provides the reader with an understanding of the principles and approaches of functional genomics and of the potential and limitations of computational and experimental approaches to genome analysis. Sequence - Evolution - Function should help bridge the "digital divide" between biologists and computer scientists, allowing biologists to better grasp the peculiarities of the emerging field of Genome Biology and to learn how to benefit from the enormous amount of sequence data available in the public databases. The book is non-technical with respect to the computer methods for genome analysis and discusses these methods from the user's viewpoint, without addressing mathematical and algorithmic details. Prior practical familiarity with the basic methods for sequence analysis is a major advantage, but a reader without such experience will be able to use the book as an introduction to these methods. This book is perfect for introductory level courses in computational methods for comparative and functional genomics.

Whole Genome Sequencing

2014

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Author: Joseph P. Damon
Publisher: Nova Science Publishers
ISBN: 9781631171574
Category : Gene mapping
Languages : en
Pages : 0

Over the course of less than a decade, whole genome sequencing has progressed from being one of our nations boldest scientific aspirations to becoming a readily available technique for determining the complete sequence of an individuals deoxyribonucleic acid (DNA) -- that persons unique genetic blueprint. This book focuses on the privacy and progress in whole genome sequencing; and provides a scientific background for policymakers in genetic testing.

Precision Cancer Medicine

2020-01-02

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Author: Sameek Roychowdhury
Publisher: Springer Nature
ISBN: 3030236374
Category : Medical
Languages : en
Pages : 196

Genomic sequencing technologies have augmented the classification of cancer beyond tissue of origin and towards a molecular taxonomy of cancer. This has created opportunities to guide treatment decisions for individual patients with cancer based on their cancer’s unique molecular characteristics, also known as precision cancer medicine. The purpose of this text will be to describe the contribution and need for multiple disciplines working together to deliver precision cancer medicine. This entails a multi-disciplinary approach across fields including molecular pathology, computational biology, clinical oncology, cancer biology, drug development, genetics, immunology, and bioethics. Thus, we have outlined a current text on each of these fields as they work together to overcome various challenges and create opportunities to deliver precision cancer medicine. As trainees and junior faculty enter their respective fields, this text will provide a framework for understanding the role and responsibility for each specialist to contribute to this team science approach.

Computational Exome and Genome Analysis

2017-09-13

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Author: Peter N. Robinson
Publisher: CRC Press
ISBN: 1351650815
Category : Computers
Languages : en
Pages : 518

Exome and genome sequencing are revolutionizing medical research and diagnostics, but the computational analysis of the data has become an extremely heterogeneous and often challenging area of bioinformatics. Computational Exome and Genome Analysis provides a practical introduction to all of the major areas in the field, enabling readers to develop a comprehensive understanding of the sequencing process and the entire computational analysis pipeline.

Whole Genome Sequencing

2022-10-05

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Author: Fouad Sabry
Publisher: One Billion Knowledgeable
ISBN:
Category : Medical
Languages : en
Pages : 386

What Is Whole Genome Sequencing The process of determining the entirety, or nearly the entirety, of the DNA sequence of an organism's genome at a single time is referred to as whole genome sequencing (WGS), full genome sequencing, complete genome sequencing, or entire genome sequencing. Other names for this process include entire genome sequencing, complete genome sequencing, and full genome sequencing. In order to do this, the chromosomal DNA of an organism, as well as the DNA found in the mitochondria and, in the case of plants, the chloroplasts, must be sequenced. How You Will Benefit (I) Insights, and validations about the following topics: Chapter 1: Whole genome sequencing Chapter 2: Genome Chapter 3: Human genome Chapter 4: Genomics Chapter 5: Molecular genetics Chapter 6: BGI Group Chapter 7: Gene duplication Chapter 8: DNA sequencing Chapter 9: Gene Chapter 10: Personal genomics Chapter 11: 1000 Genomes Project Chapter 12: Exome Chapter 13: Complete Genomics Chapter 14: Cancer genome sequencing Chapter 15: Exome sequencing Chapter 16: $1,000 genome Chapter 17: Single cell sequencing Chapter 18: Variant of uncertain significance Chapter 19: Whole genome bisulfite sequencing Chapter 20: Plant genome assembly Chapter 21: Personalized onco-genomics (II) Answering the public top questions about whole genome sequencing. (III) Real world examples for the usage of whole genome sequencing in many fields. (IV) 17 appendices to explain, briefly, 266 emerging technologies in each industry to have 360-degree full understanding of whole genome sequencing' technologies. Who This Book Is For Professionals, undergraduate and graduate students, enthusiasts, hobbyists, and those who want to go beyond basic knowledge or information for any kind of whole genome sequencing.