Neurodevelopmental Pediatrics

2023-02-22
Neurodevelopmental Pediatrics

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  • Author: David D. Eisenstat
  • Publisher: Springer Nature
  • ISBN: 3031207920
  • Category : Medical
  • Languages : en
  • Pages : 816

This book explores the interrelationship of genetics, the environment, or both, in the causation of three neurodevelopmental disorders: autism/autism spectrum disorder (ASD), fetal alcohol spectrum disorder (FASD), and cerebral palsy (CP). It links common clinical problems in developmental pediatrics and pediatric neurology to current concepts and translational research advances in developmental neurosciences, medical genetics, and related disciplines. The first section of the book provides a comprehensive and up-to-date overview of development of the brain, including topics such as neuronal stem cells, epigenetics, and the influence of the prenatal environment. The next three sections analyze the epidemiology, diagnosis, interventions, and controversies and research directions associated with each of the three neurodevelopmental disorders. It also examines co-morbidities common to all three disorders, such as disturbed sleep, seizures, behavioral disorders, and pain. It concludes by highlighting the impact of ASD, FASD, and CP on family dynamics and provides tools and resources based on foundational concepts such as neuroethics, bioinformatics, community engagement, and advocacy. Learning objectives, key points, clinical vignettes, and multiple choice questions are incorporated throughout the book. With its comprehensive treatment of disease mechanisms, genetics, and pathophysiology associated with these disorders and its discussion of potential therapies and novel treatments, Neurodevelopmental Pediatrics: Genetic and Environmental Influences is an essential resource for developmental pediatricians, child neurologists, fellows, residents and graduate students.

Neurodevelopmental Differentiation

2021-03
Neurodevelopmental Differentiation

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  • Author: Andrew Fuller
  • Publisher:
  • ISBN: 9781951075958
  • Category :
  • Languages : en
  • Pages : 248

Imagine schools where everyone learns at high levels. Not just some students. Every student. This resource aims to help educators bring these schools to life through the power of neurodevelopmental differentiation. Backed by scientific and educational research, the book outlines how to assess and build students' inherent strengths in eight major areas in order to increase engagement, mastery, and ultimately, success. Study eight brain processing systems and understand how developing strengths in these areas increases academic success. Discover how to identify students' learning strengths and needs. Learn how to develop individualized learning plans to fit the needs of all students. Contemplate reflective questions on the eight brain areas to determine next steps in your own classroom. Utilize free online reproducibles to further your understanding of the material presented in the book. Contents: Acknowledgments Table of Contents About the Authors Foreword Introduction Chapter 1: Spatial Reasoning Chapter 2: Perceptual and Motor Skills Chapter 3: Concentration and Memory Chapter 4: Planning and Sequencing Chapter 5: Thinking and Logic Chapter 6: People Smarts Chapter 7: Language and Word Smarts Chapter 8: Number Smarts Chapter 9: Implementing Neurodevelopmental Differentiation References and Resources Index

Neurodevelopmental Processes in Health and Disease: Bridging Basic and Clinical Research

2021-12-03
Neurodevelopmental Processes in Health and Disease: Bridging Basic and Clinical Research

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  • Author: Edna Grünblatt
  • Publisher: Frontiers Media SA
  • ISBN: 2889717798
  • Category : Science
  • Languages : en
  • Pages : 226

Diagnosis, Management and Modeling of Neurodevelopmental Disorders

2021-05-29
Diagnosis, Management and Modeling of Neurodevelopmental Disorders

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  • Author: Colin R Martin
  • Publisher: Academic Press
  • ISBN: 0128179899
  • Category : Psychology
  • Languages : en
  • Pages : 628

Diagnosis, Management and Modeling of Neurodevelopmental Disorders: The Neuroscience of Development is a comprehensive reference on the diagnosis and management of neurodevelopment and associated disorders. The book discusses the mechanisms underlying neurological development and provides readers with a detailed introduction to the neural connections and complexities in biological circuitries, as well as the interactions between genetics, epigenetics and other micro-environmental processes. In addition, the book also examines the pharmacological and non-pharmacological interventions of development-related conditions. - Provides the most comprehensive coverage of the broad range of topics relating to the neuroscience of aging - Features sections on the genetics that influences aging and diseases of aging - Contains an abstract, key facts, a mini dictionary of terms, and summary points in each chapter - Focuses on neurological diseases and conditions linked to aging, environmental factors and clinical recommendations - Includes more than 500 illustrations and tables

Factors Affecting Neurodevelopment

2021-05-29
Factors Affecting Neurodevelopment

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  • Author: Colin R Martin
  • Publisher: Academic Press
  • ISBN: 0128179872
  • Category : Psychology
  • Languages : en
  • Pages : 686

Factors Affecting Neurodevelopment: Genetics, Neurology, Behavior, and Diet is a comprehensive reference on the genetic and behavioral features associated with proper and abnormal development. The book discusses the mechanisms underlying neurological development and provides readers with a detailed introduction to the neural connections and complexities in biological circuitries, as well as the physiological, behavioral, molecular, and cellular features of neurodevelopment. In addition, the book examines in vitro and in vivo modeling of development with stem cells and model systems. - Provides the most comprehensive coverage of a broad range of topics relating to the neuroscience of development - Features sections on the genetics of developmental conditions and accompanying behavior - Contains an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding in each chapter - Focuses on neurodevelopmental disorders and environmental factors that influence neural development - Includes more than 500 illustrations and tables

Redox Regulation of Differentiation and De-differentiation

2021-08-26
Redox Regulation of Differentiation and De-differentiation

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  • Author: Carsten Berndt
  • Publisher: CRC Press
  • ISBN: 1000435385
  • Category : Science
  • Languages : en
  • Pages : 544

Cell differentiation and the development of multicellular organisms are processes of self-assembly, controlled and driven by signaling molecules and cascades including redox regulation. These reactions may have provided the energy for the first metabolic steps in the evolution of life. Today, redox modifications are established as important regulatory events in cellular functions including differentiation and development. Redox modifications of single cysteines regulate differentiation of stem cells, formation of functioning organs, and de-differentiation such as formation of cancer cells. Current cancer therapy is based on redox events as well and regeneration often reactivates developmental pathways. Understanding differentiation and de-differentiation on a molecular level is therefore a prerequisite for the continuing development of new medical therapies. This book summarizes the roles of redox regulation in development by bringing together different concepts and comparing similarities and differences between various cell types and species. An international team of contributors presents several new aspects of redox-regulated differentiation and de-differentiation, including aspects of redox medicine. Key Features Provides the first summary on this important topic Reviews redox-dependent development of model organisms and single organs Highlights the redox-regulated pathways important for differentiation processes Illustrates the potential of redox medicine Combines state-of-the-art knowledge in differentiation/development, aging/longevity, and repair/regeneration Written by leading experts in the field Related Titles Ayyanathan, K., ed. Cancer Cell Signaling: Targeting Signaling Pathways Toward Therapeutic Approaches to Cancer (ISBN 978-1-77188-067-1) Clarke, M. & J. Frampton. Stem Cells: Biology and Application (ISBN 9780-8153-4511-4) Lim, W. & B. Mayer. Cell Signaling: Principles and Mechanisms (ISBN 978-0-8153-4244-1) Wong, E., ed. Autophagy and Signaling (ISBN 978-0-367-65772-7)

Neurodevelopmental Disorders

2020-06-24
Neurodevelopmental Disorders

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  • Author: Emanuel DiCicco-Bloom
  • Publisher: Springer Nature
  • ISBN: 3030454932
  • Category : Medical
  • Languages : en
  • Pages : 307

This book contains a compendium of induced pluripotent stem cells (iPSCs) articles and reviews concerning state of the art technologies and how they are being applied to human neurodevelopmental disorders. With the establishment of effective technologies to produce iPSCs and their derivatives, like neural precursors, neurons, and glia, researchers have new platforms to study neurodevelopmental disorders. iPSC technology enables researchers to study how human neurons develop in individuals with neurodevelopmental disorders, providing an unparalleled opportunity to investigate their etiology. In turn, researchers have now begun to understand the underlying molecular and cellular pathways that contribute to human diseases. iPSCs technologies also provide an emerging tool for future translational studies and disease classification. The chapters will emphasize how among the diverse idiopathic and genetic disorders, there are common clinical as well as cellular and molecular phenotypes.

The Genetics of Neurodevelopmental Disorders

2015-09-28
The Genetics of Neurodevelopmental Disorders

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  • Author: Kevin J. Mitchell
  • Publisher: John Wiley & Sons
  • ISBN: 1118524888
  • Category : Medical
  • Languages : en
  • Pages : 384

Neurodevelopmental disorders arise from disturbances to various processes of brain development, which can manifest in diverse ways. They encompass many rare genetic syndromes as well as common, heritable conditions such as intellectual disability, autism, ADHD, schizophrenia and many types of epilepsy. The Genetics of Neurodevelopmental Disorders examines recent revolutionary advances in our understanding of the genetics of these disorders, exploring both basic discoveries and the translation of new findings into the clinical setting. The book begins by examining the genetic architecture and etiology of neurodevelopmental disorders. It describes the striking recent progress in identifying pathogenic mutations, which are grouped here based on the neurodevelopmental processes impacted. Subsequent chapters consider the use of cellular and animal models to elucidate the cascading consequences of such mutations, from molecular and cellular levels to emergent effects on neural circuits, brain systems and subsequent psychological development. The text concludes by examining the important clinical implications of the recent advances in the field, from recognition of the genetic causes in individual patients to development of new treatments and interventions. A timely synthesis, The Genetics of Neurodevelopmental Disorders is a unique and essential resource for neuroscientists, geneticists, neurologists and psychiatrists and an accessible and up-to-date overview for medical and science students.

Molecular and Genetic Mechanisms in Neurodevelopmental Disorders: From Bench to Bedside

2022-02-02
Molecular and Genetic Mechanisms in Neurodevelopmental Disorders: From Bench to Bedside

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  • Author: Rebecca Ann Muhle
  • Publisher: Frontiers Media SA
  • ISBN: 2889742695
  • Category : Science
  • Languages : en
  • Pages : 124

Neurodevelopmental Disorders

2020-05-24
Neurodevelopmental Disorders

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  • Author: Bin Chen
  • Publisher: Academic Press
  • ISBN: 0128144106
  • Category : Medical
  • Languages : en
  • Pages : 428

Neurodevelopmental Disorders, the latest release in the Comprehensive Developmental Neuroscience series, presents the most thorough coverage available, addressing all aspects on how the nervous system and its components develop. This book brings together the latest research in this rapidly evolving field, with section editors discussing the technological advances that are enabling the pursuit of new research on brain development. This volume focuses on neurodevelopmental disorders in humans and experimental organisms. Particular attention is paid to the effects of abnormal development and on new psychiatric/neurological treatments being developed based on our increased understanding of developmental mechanisms. - Features leading experts in various subfields as section editors and article authors - Presents articles that have been peer reviewed to ensure accuracy, thoroughness and scholarship - Covers disorders of the nervous system that arise through defects in neural development