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In order to focus on principles, each chapter in this work is brief, organized around 1-3 wiring diagrams of the key circuits, with several pages of text that distil the functional significance of each microcircuit
Microcircuits are the specific arrangements of cells and their connections that carry out the operations unique to each brain region. This resource summarizes succinctly these circuits in over 40 regions - enabling comparisons of principles across both vertebrates and invertebrates. It provides a new foundation for understanding brain function that will be of interest to all neuroscientists. Oxford Clinical Neuroscience is a comprehensive, cross-searchable collection of resources offering quick and easy access to eleven of Oxford University Press's prestigious neuroscience texts. Joining Oxford Medicine Online these resources offer students, specialists and clinical researchers the best quality content in an easy-to-access format.
Leading neuroscientists discuss the function of microcircuits, functional modules that act as elementary processing units bridging single cells to systems and behavior. Microcircuits, functional modules that act as elementary processing units bridging single cells to systems and behavior, could provide the link between neurons and global brain function. Microcircuits are designed to serve particular functions; examples of these functional modules include the cortical columns in sensory cortici, glomeruli in the olfactory systems of insects and vertebrates, and networks generating different aspects of motor behavior. In this Dahlem Workshop volume, leading neuroscientists discuss how microcircuits work to bridge the single cell and systems levels and compare the intrinsic function of microcircuits with their ion channel subtypes, connectivity, and receptors, in order to understand the design principles and function of the microcircuits. The chapters cover the four major areas of microcircuit research: motor systems, including locomotion, respiration, and the saccadic eye movements; the striatum, the largest input station of the basal ganglia; olfactory systems and the neural organization of the glomeruli; and the neocortex. Each chapter is followed by a group report, a collaborative discussion among senior scientists. Contributors Lidia Alonso-Nanclares, Hagai Bergman, Maria Blatow, J. Paul Bolam, Ansgar Büschges, Antonio Caputi, Jean-Pierre Changeux, Javier DeFelipe, Carsten Duch, Paul Feinstein, Stuart Firestein, Yves Frégnac, Rainer W. Friedrich, C. Giovanni Galizia, Ann M. Graybiel, Charles A. Greer, Sten Grillner, Tadashi Isa, Ole Kiehn, Minoru Kimura, Anders Lanser, Gilles Laurent, Pierre-Marie Lledo, Wolfgang Maass, Henry Markram, David A. McCormick, Christoph M. Michel, Peter Mombaerts, Hannah Monyer, Hans-Joachim Pflüger, Dietmar Plenz, Diethelm W. Richter, Silke Sachse, H. Sebastian Seung, Keith T. Sillar, Jeffrey C. Smith, David L. Sparks, D. James Surmeier, Eörs Szathmáry, James M. Tepper, Jeff R. Wickens, Rafael Yuste
In his new book, Gordon M. Shepherd expands on the startling discovery that the brain creates the taste of wine. This approach to understanding wine's sensory experience draws on findings in neuroscience, biomechanics, human physiology, and traditional enology. Shepherd shows, just as he did in Neurogastronomy: How the Brain Creates Flavor and Why It Matters, that creating the taste of wine engages more of the brain than does any other human behavior. He clearly illustrates the scientific underpinnings of this process, along the way enhancing our enjoyment of wine. Neuroenology is the first book on wine tasting by a neuroscientist. It begins with the movements of wine through the mouth and then consults recent research to explain the function of retronasal smell and its extraordinary power in creating wine taste. Shepherd comprehensively explains how the specific sensory pathways in the cerebral cortex create the memory of wine and how language is used to identify and imprint wine characteristics. Intended for a broad audience of readers—from amateur wine drinkers to sommeliers, from casual foodies to seasoned chefs—Neuroenology shows how the emotion of pleasure is the final judge of the wine experience. It includes practical tips for a scientifically informed wine tasting and closes with a delightful account of Shepherd's experience tasting classic Bordeaux vintages with French winemaker Jean-Claude Berrouet of the Chateau Petrus and Dominus Estate.
Depending on your point of view the brain is an organ, a machine, a biological computer, or simply the most important component of the nervous system. How does it work as a whole? What are its major parts and how are they interconnected to generate thinking, feelings, and behavior? This book surveys 2,500 years of scientific thinking about these profoundly important questions from the perspective of fundamental architectural principles, and then proposes a new model for the basic plan of neural systems organization based on an explosion of structural data emerging from the neuroanatomy revolution of the 1970's. The importance of a balance between theoretical and experimental morphology is stressed throughout the book. Great advances in understanding the brain's basic plan have come especially from two traditional lines of biological thought-- evolution and embryology, because each begins with the simple and progresses to the more complex. Understanding the organization of brain circuits, which contain thousands of links or pathways, is much more difficult. It is argued here that a four-system network model can explain the structure-function organization of the brain. Possible relationships between neural networks and gene networks revealed by the human genome project are explored in the final chapter. The book is written in clear and sparkling prose, and it is profusely illustrated. It is designed to be read by anyone with an interest in the basic organization of the brain, from neuroscience to philosophy to computer science to molecular biology. It is suitable for use in neuroscience core courses because it presents basic principles of the structure of the nervous system in a systematic way.
Essays that explore quirky, counterintuitive aspects of brain function and “make us realize that what goes on in our minds is nothing short of magical” (Scientific American). Neuroscientist David J. Linden approached leading brain researchers and asked each the same question: “What idea about brain function would you most like to explain to the world?” Their responses make up this one-of-a-kind collection of popular science essays that seeks to expand our knowledge of the human mind and its possibilities. The contributors, whose areas of expertise include human behavior, molecular genetics, evolutionary biology, and comparative anatomy, address a host of fascinating topics ranging from personality to perception, to learning, to beauty, to love and sex. The manner in which individual experiences can dramatically change our brains’ makeup is explored. Professor Linden and his contributors open a new window onto the landscape of the human mind and into the cutting-edge world of neuroscience with a fascinating, enlightening compilation that science enthusiasts and professionals alike will find accessible and enjoyable. “Scientists who can effectively communicate science are rare, but here are forty of the best, describing with clarity and enthusiasm the latest in brain research and its impact on our lives.” —Gordon M. Shepherd, co-editor of Handbook of Brain Microcircuits
The Ocular Inflammatory Disease and Uveitis Manual is a practical, concise clinical reference for resident and practicing ophthalmologists and optometrists treating uveitis patients and an excellent review for the OKAP exam and ophthalmology and optometry boards. Designed for quick point-of-care reference, the book features numerous full-color photographs and bulleted how-to instructions for workup and treatment of each disorder. The state-of-the-art coverage of medical and surgical treatment includes drugs expected to be approved in 2010. The manual is organized into anterior, intermediate, and posterior disease, plus separate sections for corneal and sclera inflammation and infection masquerading syndromes. All topics are further divided into autoimmune and infectious sections, for quick lookup of a disorder.
What is the nature of human creativity? What are the brain processes behind its mystique? What are the evolutionary roots of creativity? How does culture help shape individual creativity? Creativity: The Human Brain in the Age of Innovation by Elkhonon Goldberg is arguably the first ever book to address these and other questions in a way that is both rigorous and engaging, demystifying human creativity for the general public. The synthesis of neuroscience and the humanities is a unique feature of the book, making it of interest to an unusually broad range of readership. Drawing on a number of cutting-edge discoveries from brain research as well as on his own insights as a neuroscientist and neuropsychologist, Goldberg integrates them with a wide-ranging discussion of history, culture, and evolution to arrive at an original, compelling, and at times provocative understanding of the nature of human creativity. To make his argument, Goldberg discusses the origins of language, the nature of several neurological disorders, animal cognition, virtual reality, and even artificial intelligence. In the process, he takes the reader to different times and places, from antiquity to the future, and from Western Europe to South-East Asia. He makes bold predictions about the future directions of creativity and innovation in society, their multiple biological and cultural roots and expressions, about how they will shape society for generations to come, and even how they will change the ways the human brain develops and ages.
"The question for me is how can the human mind occur in the physical universe. We now know that the world is governed by physics. We now understand the way biology nestles comfortably within that. The issue is how will the mind do that as well."--Allen Newell, December 4, 1991, Carnegie Mellon University The argument John Anderson gives in this book was inspired by the passage above, from the last lecture by one of the pioneers of cognitive science. Newell describes what, for him, is the pivotal question of scientific inquiry, and Anderson gives an answer that is emerging from the study of brain and behavior. Humans share the same basic cognitive architecture with all primates, but they have evolved abilities to exercise abstract control over cognition and process more complex relational patterns. The human cognitive architecture consists of a set of largely independent modules associated with different brain regions. In this book, Anderson discusses in detail how these various modules can combine to produce behaviors as varied as driving a car and solving an algebraic equation, but focuses principally on two of the modules: the declarative and procedural. The declarative module involves a memory system that, moment by moment, attempts to give each person the most appropriate possible window into his or her past. The procedural module involves a central system that strives to develop a set of productions that will enable the most adaptive response from any state of the modules. Newell argued that the answer to his question must take the form of a cognitive architecture, and Anderson organizes his answer around the ACT-R architecture, but broadens it by bringing in research from all areas of cognitive science, including how recent work in brain imaging maps onto the cognitive architecture.
This book provides a broad survey of the field of biochips, including fundamentals of microelectronics and biomaterials interaction with various, living tissues, as well as numerous, diverse applications. Although a wide variety of biochips will be described, there will be a focus on those at the brain-machine interface. Analysis is included of the relationship between different categories of biochips and their interactions with the body and coverage includes wireless remote control of biochips and arrays of microelectrodes, based on new biomaterials.
