Bottle of Lies

Bottle of Lies

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  • Author: Katherine Eban
  • Publisher: HarperCollins
  • ISBN: 0063054108
  • Category : Medical
  • Languages : en
  • Pages : 523

A NEW YORK TIMES BESTSELLER * New York Times Notable Book * Best Book of the Year: New York Public Library, Kirkus Reviews, Science Friday With a new postscript by the author From an award-winning journalist, an explosive narrative investigation of the generic drug boom that reveals fraud and life-threatening dangers on a global scale—The Jungle for pharmaceuticals Many have hailed the widespread use of generic drugs as one of the most important public-health developments of the twenty-first century. Today, almost 90 percent of our pharmaceutical market is comprised of generics, the majority of which are manufactured overseas. We have been reassured by our doctors, our pharmacists and our regulators that generic drugs are identical to their brand-name counterparts, just less expensive. But is this really true? Katherine Eban’s Bottle of Lies exposes the deceit behind generic-drug manufacturing—and the attendant risks for global health. Drawing on exclusive accounts from whistleblowers and regulators, as well as thousands of pages of confidential FDA documents, Eban reveals an industry where fraud is rampant, companies routinely falsify data, and executives circumvent almost every principle of safe manufacturing to minimize cost and maximize profit, confident in their ability to fool inspectors. Meanwhile, patients unwittingly consume medicine with unpredictable and dangerous effects. The story of generic drugs is truly global. It connects middle America to China, India, sub-Saharan Africa and Brazil, and represents the ultimate litmus test of globalization: what are the risks of moving drug manufacturing offshore, and are they worth the savings? A decade-long investigation with international sweep, high-stakes brinkmanship and big money at its core, Bottle of Lies reveals how the world’s greatest public-health innovation has become one of its most astonishing swindles.


Bottles of Lies

Bottles of Lies

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  • Author: Katherine Eban
  • Publisher:
  • ISBN: 9789353450441
  • Category : Drug adulteration
  • Languages : en
  • Pages : 0

"Many have hailed the widespread use of generic drugs as one of the most important public-health developments of the twenty-first century. Today, almost 90 percent of our pharmaceutical market is comprised of generics, the majority of which are manufactured overseas. We have been reassured by our doctors, our pharmacists and our regulators that generic drugs are identical to their brand-name counterparts, just less expensive. But is this really true? Katherine Eban's Bottle of Lies exposes the deceit behind generic-drug manufacturing--and the attendant risks for global health. Drawing on exclusive accounts from whistleblowers and regulators, as well as thousands of pages of confidential FDA documents, Eban reveals an industry where fraud is rampant, companies routinely falsify data, and executives circumvent almost every principle of safe manufacturing to minimize cost and maximize profit, confident in their ability to fool inspectors. Meanwhile, patients unwittingly consume medicine with unpredictable and dangerous effects. The story of generic drugs is truly global. It connects middle America to China, India, sub-Saharan Africa and Brazil, and represents the ultimate litmus test of globalization: what are the risks of moving drug manufacturing offshore, and are they worth the savings?"--Dust jacket.


Dangerous Doses

Dangerous Doses

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  • Author: Katherine Eban
  • Publisher: Houghton Mifflin Harcourt
  • ISBN: 9780156030854
  • Category : Medical
  • Languages : en
  • Pages : 479

An exploration of drug counterfeiting activities in America traces a drug theft investigation in Florida with ties to a national network of drug polluters and the government, exposing how political interests may be compromising the integrity of the nation's medical distribution system. Reprint. 30,000 first printing.


Pharma

Pharma

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  • Author: Gerald Posner
  • Publisher: Simon and Schuster
  • ISBN: 1501152033
  • Category : Business & Economics
  • Languages : en
  • Pages : 816

"Exorbitant prices for lifesaving drugs, safety recalls affecting tens of millions of Americans, and soaring rates of addiction and overdose on prescription opioids have caused many to lose faith in pharmaceutical companies. Now, Americans are demanding national reckoning with a monolithic industry. In Pharma, award-winning journalist and New York Times best-selling author Gerald Posner uncovers the real story of the Sacklers, the family that became one of America's wealthiest from the success of OxyContin, their blockbuster narcotic painkiller at the centure of the opioid crisis. The unexpected twists and turns of the Sakler family saga are told against the startling chronicle of a powerful industry that sits at the intersection of public health and profits. Pharma reveals how and why American drug companies have put earnings ahead of patients"--


Drug Repurposing

Drug Repurposing

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  • Author: David Cavalla
  • Publisher: Royal Society of Chemistry
  • ISBN: 1839163402
  • Category : Medical
  • Languages : en
  • Pages : 350

Drug repurposing is the development of existing drugs for new uses: given that 9 in 10 drugs that enter drug development are never marketed and therefore represent wasted effort, it is an attractive as well as inherently more efficient process. Three repurposed drugs can be brought to market for the same cost as one new chemical entity; and they can also be identified more quickly, an important benefit for patients whose diseases are progressing faster than therapeutic innovation. But repurposing also requires a fresh look at configuring pharmaceutical R&D, considering clinical, regulatory and patent issues much earlier than would otherwise be the case; a holistic gedanken experiment almost needs to be undertaken at the very start of any repurposing development. In addition to new ways of thinking, the discovery of repurposing opportunities can take advantage of artificial intelligence techniques to match the perfect new use for an existing drug. And while repurposing of medicines has been in the mind of every doctor since Hypocrates, modern clinical practice will simply have to adapt to new repurposing techniques in an age where the number of known diseases is increasing much faster than the healthcare dollars available.


The Comfort of Lies

The Comfort of Lies

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  • Author: Randy Susan Meyers
  • Publisher: Simon and Schuster
  • ISBN: 1451673035
  • Category : Fiction
  • Languages : en
  • Pages : 352

“Happiness at someone else’s expense came at a price. Tia had imagined judgment from the first kiss that she and Nathan shared. All year, she’d waited to be punished for being in love, and in truth, she believed that whatever consequences came her way would be deserved.” Five years ago, Tia fell into obsessive love with a man she could never have. Married, and the father of two boys, Nathan was unavailable in every way. When she became pregnant, he disappeared, and she gave up her baby for adoption. Five years ago, Caroline, a dedicated pathologist, reluctantly adopted a baby to please her husband. She prayed her misgivings would disappear; instead, she’s questioning whether she’s cut out for the role of wife and mother. Five years ago, Juliette considered her life ideal: she had a solid marriage, two beautiful young sons, and a thriving business. Then she discovered Nathan’s affair. He promised he’d never stray again, and she trusted him. But when Juliette intercepts a letter to her husband from Tia that contains pictures of a child with a deep resemblance to her husband, her world crumbles once more. How could Nathan deny his daughter? And if he’s kept this a secret from her, what else is he hiding? Desperate for the truth, Juliette goes in search of the little girl. And before long, the three women and Nathan are on a collision course with consequences that none of them could have predicted. Riveting and arresting, The Comfort of Lies explores the collateral damage of infidelity and the dark, private struggles many of us experience but rarely reveal.


Sickening

Sickening

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  • Author: John Abramson
  • Publisher: HarperCollins
  • ISBN: 1328956989
  • Category : Health & Fitness
  • Languages : en
  • Pages : 336

The inside story of how Big Pharma’s relentless pursuit of ever-higher profits corrupts medical knowledge—misleading doctors, misdirecting American health care, and harming our health. The United States spends an excess $1.5 trillion annually on health care compared to other wealthy countries—yet the amount of time that Americans live in good health ranks a lowly 68th in the world. At the heart of the problem is Big Pharma, which funds most clinical trials and therefore controls the research agenda, withholds the real data from those trials as corporate secrets, and shapes most of the information relied upon by health care professionals. In this no-holds-barred exposé, Dr. John Abramson—one of the foremost experts on the drug industry’s deceptive tactics—combines patient stories with what he learned during many years of serving as an expert in national drug litigation to reveal the tangled web of financial interests at the heart of the dysfunction in our health-care system. For example, one of pharma’s best-kept secrets is that the peer reviewers charged with ensuring the accuracy and completeness of the clinical trial reports published in medical journals do not even have access to complete data and must rely on manufacturer-influenced summaries. Likewise for the experts who write the clinical practice guidelines that define our standards of care. The result of years of research and privileged access to the inner workings of the U.S. medical-industrial complex, Sickening shines a light on the dark underbelly of American health care—and presents a path toward genuine reform.


The Bourbon Thief

The Bourbon Thief

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  • Author: Tiffany Reisz
  • Publisher: MIRA
  • ISBN: 1459293991
  • Category : Fiction
  • Languages : en
  • Pages : 230

From the bestselling author of the Original Sinners series comes a tale of betrayal, revenge and a family scandal that bore a 150-year-old mystery. When Cooper McQueen wakes up from a night with a beautiful stranger, it’s to discover he’s been robbed. The only item stolen—a million-dollar bottle of bourbon. The thief, a mysterious woman named Paris, claims the bottle is rightfully hers. After all, the label itself says it’s property of the Maddox family who owned and operated Red Thread Bourbon distillery since the last days of the Civil War until the company went out of business for reasons no one knows . . . No one except Paris. In the small hours of a Louisville morning, Paris unspools the lurid tale of Tamara Maddox, heiress to the distillery that became an empire. But the family tree is rooted in tainted soil and has borne rotten fruit. Theirs is a legacy of wealth and power, but also of lies, secrets and sins of omission. The Maddoxes have bourbon in their blood—and blood in their bourbon. Why Paris wants the bottle of Red Thread remains a secret until the truth of her identity is at last revealed, and the century-old vengeance Tamara vowed against her family can finally be completed. “A dark, twisty tale of love, lust, betrayal, and murder . . . this novel is not one to be missed.” —Bustle “Reisz holds her readers hostage with her stunning poetic prose, intensity, raw emotions, and her vivid suspenseful story line . . . wickedly addicting.” —Manhattan Book Review “Had me engrossed from the first page. Ms. Reisz’s writing is captivating.” —Fresh Fiction


The Right Price

The Right Price

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  • Author: Peter J. Neumann
  • Publisher: Oxford University Press
  • ISBN: 0197512887
  • Category : Health & Fitness
  • Languages : en
  • Pages : 273

The US prescription drug business is a $500 billion industry whose rising prices carry profound consequences for patients, caregivers, employers and taxpayers across the nation. In the United States, average prices of leading brand-name drugs are two to four times higher than prices charged in other wealthy countries, raising questions as to what Americans are getting for the extra expense. On the other hand, healthy industry returns have arguably fueled life-saving innovation. With the advent of ever more targeted and powerful treatments, including cell- and gene-based therapies with multi-million-dollar price tags, the need for sensible drug pricing policies will only intensify. The Right Price sheds light on the controversial topic of drug pricing by providing an accessible guide to pharmaceutical markets and analytic techniques used to measure the value of drug therapies. It illustrates the need for value-based pricing through real-life stories of patients and their experiences with the drug industry and explains why simple solutions like price controls and the importation of cheaper drugs from other countries are problematic. This volume describes how researchers and policy makers have pursued drug valuation efforts in the past, and lays out a series of recommendations, based on years of shared author experience serving on national drug policy platforms, for how to further improve pharmaceutical value assessment in the United States. With unique industry insights and clear narrative, The Right Price unveils why the pricing of drugs continues to be so challenging and how public and private officials can create more informed policies to achieve the right balance between drug pricing and value.


Tell Me Lies

Tell Me Lies

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  • Author: Carola Lovering
  • Publisher: Simon and Schuster
  • ISBN: 1501169661
  • Category : Fiction
  • Languages : en
  • Pages : 384

Now an original series on Hulu! Catch up on Season 1...Season 2 streaming now! “A twisted modern love story” (Parade), Tell Me Lies is a sexy, thrilling novel about that one person who still haunts you—the other one. The wrong one. The one you couldn’t let go of. The one you’ll never forget. Lucy Albright is far from her Long Island upbringing when she arrives on the campus of her small California college and happy to be hundreds of miles from her mother—whom she’s never forgiven for an act of betrayal in her early teen years. Quickly grasping at her fresh start, Lucy embraces college life and all it has to offer. And then she meets Stephen DeMarco. Charming. Attractive. Complicated. Devastating. Confident and cocksure, Stephen sees something in Lucy that no one else has, and she’s quickly seduced by this vision of herself, and the sense of possibility that his attention brings her. Meanwhile, Stephen is determined to forget an incident buried in his past that, if exposed, could ruin him, and his single-minded drive for success extends to winning, and keeping, Lucy’s heart. Lucy knows there’s something about Stephen that isn’t to be trusted. Stephen knows Lucy can’t tear herself away. And their addicting entanglement will have consequences they never could have imagined. Alternating between Lucy’s and Stephen’s voices, Tell Me Lies follows their connection through college and post-college life in New York City. “Readers will be enraptured” (Booklist) by the “unforgettable beauties in this very sexy story” (Kirkus Review). With the psychological insight and biting wit of Luckiest Girl Alive, and the yearning ambitions and desires of Sweetbitter, this keenly intelligent and supremely resonant novel chronicles the exhilaration and dilemmas of young adulthood and the difficulty of letting go—even when you know you should.