Bioinformatics for High Throughput Sequencing

2011-10-26
Bioinformatics for High Throughput Sequencing

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  • Author: Naiara Rodríguez-Ezpeleta
  • Publisher: Springer Science & Business Media
  • ISBN: 1461407826
  • Category : Science
  • Languages : en
  • Pages : 258

Next generation sequencing is revolutionizing molecular biology. Owing to this new technology it is now possible to carry out a panoply of experiments at an unprecedented low cost and high speed. These go from sequencing whole genomes, transcriptomes and small non-coding RNAs to description of methylated regions, identification protein – DNA interaction sites and detection of structural variation. The generation of gigabases of sequence information for each of this huge bandwidth of applications in just a few days makes the development of bioinformatics applications for next generation sequencing data analysis as urgent as challenging.

Beginners Guide to Bioinformatics for High Throughput Sequencing

2018
Beginners Guide to Bioinformatics for High Throughput Sequencing

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  • Author: Hugh T. W. Tan
  • Publisher:
  • ISBN: 9789813230521
  • Category : Bioinformatics
  • Languages : en
  • Pages :

Beginners Guide To Bioinformatics For High Throughput Sequencing

2018-10-05
Beginners Guide To Bioinformatics For High Throughput Sequencing

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  • Author: Tan Tin Wee
  • Publisher: World Scientific
  • ISBN: 9813230533
  • Category : Computers
  • Languages : en
  • Pages : 276

Biologists find computing bewildering; yet they are expected to be able to process the voluminous data available from the machines they buy and the datasets that has accumulated in genomic databanks worldwide. It is now increasingly difficult for them to avoid dealing with large volumes of data, that goes beyond just doing manual programming.Most books in this realm are full of equations and complex code but this book gives a much gentler entry point particularly for biologists, with code snippets users can use to cut and paste, and run on their Linux or MacOSX operating system or cloud instance. It also provides a step by step installation instructions which they can easily follow. Those who are in the field of genome sequencing and already familiar with the procedures of analysis, may also find this book useful in closing some knowledge gaps.High throughput sequencing requires high throughput and high performance computing. This book provides a gentle entry to high throughput sequencing by dealing with simple skills which the average biologist is increasingly required to master. You will find this book a breeze to read, and some suggestions in this book maybe new to you, something you might want to try out.

Genome-Scale Algorithm Design

2023-10-12
Genome-Scale Algorithm Design

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  • Author: Veli Mäkinen
  • Publisher: Cambridge University Press
  • ISBN: 1009341219
  • Category : Computers
  • Languages : en
  • Pages : 470

Guided by standard bioscience workflows in high-throughput sequencing analysis, this book for graduate students, researchers, and professionals in bioinformatics and computer science offers a unified presentation of genome-scale algorithms. This new edition covers the use of minimizers and other advanced data structures in pangenomics approaches.

Bioinformatics for agriculture: High-throughput approaches

2021-03-19
Bioinformatics for agriculture: High-throughput approaches

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  • Author: Atul Kumar Upadhyay
  • Publisher: Springer Nature
  • ISBN: 9813347910
  • Category : Science
  • Languages : en
  • Pages : 160

This book illustrates the importance and significance of bioinformatics in the field of agriculture. It first introduces the basic concepts of bioinformatics, such as homologous sequence and gene function analyses, determination of protein structures, and discusses machine learning applications for an in-depth understanding of the desired genes and proteins based on commonly used bioinformatics software and tools, e.g. BLAST, molecular modelling, molecular-docking and simulations, protein-protein and domain-domain interactions. The book also describes recent advances in the high-throughput analysis of whole genome and transcriptome using next-generation sequencing platforms, and functional proteome studies. It also examines the role of computational biology in understanding and improving the nutrient quality and yield of crops. Lastly, the book explores a comprehensive list of applications of bioinformatics to improve plant yield, biomass, and health, and the challenges involved.

High-Throughput Next Generation Sequencing

2011-03-22
High-Throughput Next Generation Sequencing

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  • Author: Young Min Kwon
  • Publisher: Humana Press
  • ISBN: 9781617790881
  • Category : Medical
  • Languages : en
  • Pages : 0

Due to their novel concepts and extraordinary high-throughput sequencing capacity, the “next generation sequencing” methods allow scientists to grasp system-wide landscapes of the complex molecular events taking place in various biological systems, including microorganisms and microbial communities. These methods are now being recognized as essential tools for a more comprehensive and deeper understanding of the mechanisms underlying many biological processes. In High-Throughput Next Generation Sequencing: Methods and Applications, experts in the field explore the most recent advances in the applications of next generation sequencing technologies with an emphasis on microorganisms and their communities; however, the methods described in this book will also offer general applications relevant to the study of any living organisms. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, High-Throughput Next Generation Sequencing: Methods and Applications is an excellent collection of chapters to aid all scientists who wish to apply these innovative research tools to enhance their own pursuits in microbiology and also biology in general.

Advances in Bioinformatics

2021-07-31
Advances in Bioinformatics

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  • Author: Vijai Singh
  • Publisher: Springer Nature
  • ISBN: 9813361913
  • Category : Science
  • Languages : en
  • Pages : 446

This book presents the latest developments in bioinformatics, highlighting the importance of bioinformatics in genomics, transcriptomics, metabolism and cheminformatics analysis, as well as in drug discovery and development. It covers tools, data mining and analysis, protein analysis, computational vaccine, and drug design. Covering cheminformatics, computational evolutionary biology and the role of next-generation sequencing and neural network analysis, it also discusses the use of bioinformatics tools in the development of precision medicine. This book offers a valuable source of information for not only beginners in bioinformatics, but also for students, researchers, scientists, clinicians, practitioners, policymakers, and stakeholders who are interested in harnessing the potential of bioinformatics in many areas.

Biological Sequence Analysis

1998-04-23
Biological Sequence Analysis

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  • Author: Richard Durbin
  • Publisher: Cambridge University Press
  • ISBN: 113945739X
  • Category : Science
  • Languages : en
  • Pages : 372

Probabilistic models are becoming increasingly important in analysing the huge amount of data being produced by large-scale DNA-sequencing efforts such as the Human Genome Project. For example, hidden Markov models are used for analysing biological sequences, linguistic-grammar-based probabilistic models for identifying RNA secondary structure, and probabilistic evolutionary models for inferring phylogenies of sequences from different organisms. This book gives a unified, up-to-date and self-contained account, with a Bayesian slant, of such methods, and more generally to probabilistic methods of sequence analysis. Written by an interdisciplinary team of authors, it aims to be accessible to molecular biologists, computer scientists, and mathematicians with no formal knowledge of the other fields, and at the same time present the state-of-the-art in this new and highly important field.

Advances in Statistical Bioinformatics

2013-06-10
Advances in Statistical Bioinformatics

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  • Author: Kim-Anh Do
  • Publisher: Cambridge University Press
  • ISBN: 1107027527
  • Category : Mathematics
  • Languages : en
  • Pages : 499

This book describes the integration of high-throughput bioinformatics data from multiple platforms to inform our understanding of the functional consequences of genomic alterations.

Molecular Biology - Not Only for Bioinformaticians

2013-12-05
Molecular Biology - Not Only for Bioinformaticians

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  • Author: Wiesława Widłak
  • Publisher: Springer
  • ISBN: 3642453619
  • Category : Computers
  • Languages : en
  • Pages : 159

Bioinformatics, which can be defined as the application of computer science and information technology to the field of biology and medicine, has been rapidly developing over the past few decades. It generates new knowledge as well as the computational tools to create that knowledge. Understanding the basic processes in living organisms is therefore indispensable for bioinformaticians. This book addresses beginners in molecular biology, especially computer scientists who would like to work as bioinformaticians. It presents basic processes in living organisms in a condensed manner. Additionally, principles of several high-throughput technologies in molecular biology, which need the assistance of bioinformaticians, are explained from a biological point of view. It is structured in the following 9 chapters: cells and viruses; protein structure and function; nucleic acids; DNA replication, mutations, and repair; transcription and posttranscriptional processes; synthesis and posttranslational modifications of proteins; cell division; cell signaling pathways; and high-throughput technologies in molecular biology.