The Neuroscience of Autism Spectrum Disorders

2012-10-25
The Neuroscience of Autism Spectrum Disorders

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  • Author: Joseph D. Buxbaum
  • Publisher: Academic Press
  • ISBN: 012391924X
  • Category : Medical
  • Languages : en
  • Pages : 494

Autism is no longer considered a rare disease, and the Center for Disease Control now estimates that upwards of 730,000 children in the US struggle with this isolating brain disorder. New research is leading to greater understanding of and ability to treat the disorder at an earlier age. It is hoped that further genetic and imaging studies will lead to biologically based diagnostic techniques that could help speed detection and allow early, more effective intervention. Edited by two leaders in the field, this volume offers a current survey and synthesis of the most important findings of the neuroscience behind autism of the past 20 years. With chapters authored by experts in each topic, the volume explores etiology, neuropathology, imaging, and pathways/models. Offering a broad background of ASDs with a unique focus on neurobiology, the volume offers more than the others on the market with a strictly clinical focus or a single authored perspective that fails to offer expert, comprehensive coverage. Researchers and graduate students alike with an interest in developmental disorders and autism will benefit, as will autism specialists across psychology and medicine looking to expand their expertise. Uniquely explores ASDs from a neurobiological angle, looking to uncover the molecular/cellular basis rather than to merely catalog the commonly used behavioral interventions Comprehensive coverage synthesizes widely dispersed research, serving as one-stop shopping for neurodevelopmental disorder researchers and autism specialists Edited work with chapters authored by leaders in the field around the globe - the broadest, most expert coverage available

The Neuroscience of Autism

2022-05-27
The Neuroscience of Autism

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  • Author: Rajesh K. Kana
  • Publisher: Academic Press
  • ISBN: 012816736X
  • Category : Education
  • Languages : en
  • Pages : 298

The Neuroscience of Autism provides a comprehensive accounting of autism spectrum disorders by integrating scientific findings from behavioral, cognitive and neurobiological research. The book begins by defining autism, identifying characteristics and prevalence, exploring its history, and then moving on to the cognitive and social bases of behavioral symptoms, the brain bases of behavioral and cognitive symptoms, and finally, intervention practices. It examines theoretical models such as weak central coherence, enhanced perceptual functioning, and the extreme male brain hypothesis. Finally, the book addresses the increased attention on the brain connectivity model of autism, looking at the synchronization of brain activity across different brain areas, the causal influence of a brain region on another, and white matter cable connections in the brain. Delves into the increasing prevalence of autism in the United States Focuses on screening tools for early identification Discusses the neuroanatomical differences seen in individuals with autism Examines the inferences gained from functional MRI studies of autism

The Neurobiology of Autism

2005
The Neurobiology of Autism

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  • Author: Margaret L. Bauman
  • Publisher: JHU Press
  • ISBN: 9780801880476
  • Category : Medical
  • Languages : en
  • Pages : 428

In the decade since the first edition of The Neurobiology of Autism was published, research has revealed valuable new information about the nature and origins of autism, including genetics and abnormalities in such neurotransmitters as acetylcholine and serotonin. For this long-anticipated new edition, neurologists Margaret L. Bauman and Thomas L. Kemper bring together leading researchers and clinicians to present the most current scientific knowledge and theories about autism. The contributors cover genetics, imaging studies, physiology, neuroanatomy and neurochemistry, immunology, brain function, the epidemiology of the disease, and related disorders. Thoroughly updated, The Neurobiology of Autism remains the best single-volume work on the wide array of research being conducted into the causes, characteristics, and treatment of autism. Contributors: George M. Anderson, Yale Child Study Center; Tara L. Arndt, University of Rochester Medical Center (URMC); Trang Au, University of Massachusetts Medical School (UMMC); Jocelyne Bachevalier, University of Texas Health Science Center; Irina N. Bespalova, Seaver Autism Research Center, Mt. Sinai School of Medicine (SARC); Gene J. Blatt, Boston University School of Medicine (BUSM); Susan E. Bryson, IWK Health Centre–Dalhousie University; Timothy M. Buie, Massachusetts General Hospital (MGH); Joseph D. Buxbaum, SARC; Kathryn M. Carbone, The Johns Hopkins University School of Medicine (JHUSM); Diane C. Chugani, Wayne State University; Daniel F. Connor, UMMC; Edwin H. Cook, Jr., University of Chicago; S. Hossein Fatemi, University of Minnesota Medical School; Susan E. Folstein, Tufts University School of Medicine; Eric Fombonne, McGill University; Randi Jenssen Hagerman, UC Davis Medical Center; Elizabeth Petri Henske, Fox Chase Cancer Center, Philadelphia; Jeannette J. A. Holden, Queen's University; Ronald J. Killiany, BUSM; Omanand Koul, UMMC; Mandy Lee, Newcastle General Hospital, U.K.; Xudong Liu, Queen's University; Tara L. Moore, BUSM; Mark B. Moss, BUSM; Karin B. Nelson, National Institute of Neurological Disorders and Stroke; Phillip G. Nelson, National Institute of Child Health and Human Development; Elaine Perry, Newcastle General Hospital; Jonathan Pevsner, JHUSM; Mikhail V. Pletnikov, JHUSM; Stephen W. Porges, University of Illinois at Chicago; Lucio Rehbein, Universidad de la Frontera, Chile; Jennifer Reichert, SARC; Patricia M. Rodier, URMC; Beth Rosen-Sheidley, MGH; Susan L. Smalley, UCLA Neuropsychiatric Research Institute; Ronald J. Steingard, UMMC; Helen Tager-Flusberg, BUSM; Gary L. Wenk, University of Arizona; Andrew W. Zimmerman, JHUSM

Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability

2016-04-30
Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability

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  • Author: Carlo Sala
  • Publisher: Academic Press
  • ISBN: 0128005335
  • Category : Medical
  • Languages : en
  • Pages : 394

Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability provides the latest information on Autism spectrum disorders (ASDs), the lifelong neurodevelopmental disorders that present in early childhood and affect how individuals communicate and relate to others and their surroundings. In addition, three quarters of ASD patients also manifest severe intellectual disability. Though certain genes have been implicated, ASDs remain largely a mystery, and research looking into causes and cellular deficits are crucial for better understanding of neurodevelopmental disorders. Despite the prevalence and insidious nature of this disorder, this book remains to be an extensive resource of information and background on the state of current research in the field. The book serves as a reference for this purpose, and discusses the crucial role synaptic activity plays in proper brain function. In addition, the volume discusses the neurodevelopmental synaptopathies and serves as a resource for scientists and clinicians in all biomedical science specialties. This research has been crucial for recent studies that have provided a rationale for the development of pharmacological agents able to counteract functional synaptic anomalies and potentially ameliorate some ASD symptoms. Introduces the genetic and non-genetic causes of autism and associated intellectual disabilities Describes the genes implicated in autistic spectrum disorders and their function Considers major individual genetic causes of autism, Rett syndrome, Fragile X syndrome, and other autism spectrum disorders, as well as their classification as synaptopathies Presents a thorough discussion of the clinical aspects of multiple neurodevelopmental disorders and the experimental models that exist to study their pathophysiology in vitro and in vivo, including animal models and patient-derived stem cell culture

Autism Spectrum Disorder

2013-11-14
Autism Spectrum Disorder

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  • Author: Susan P. Sherkow
  • Publisher: Rowman & Littlefield
  • ISBN: 0765708639
  • Category : Psychology
  • Languages : en
  • Pages : 232

Autism Spectrum Disorder: Perspectives from Psychoanalysis and Neuroscience, offers a guide to understanding and treating the ASD toddler from the dual perspectives of psychoanalysis and neurofunction through describing in great detail intensive treatments of four children who began therapy as toddlers. The authors hypothesize that dyadic therapy and Reflective Network Therapy can impact a child by modifying the biochemistry of the brain, resulting in alteration of emotion and cognition. Their chapter on neurobiological mechanisms of change describes these hypotheses in depth.

Autism Spectrum Disorders

2021
Autism Spectrum Disorders

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  • Author: Andreas M. Grabrucker
  • Publisher:
  • ISBN:
  • Category :
  • Languages : en
  • Pages : 117

Autism spectrum disorders are developmental disorders. Individuals with autism spectrum disorders develop differently. These differences are usually present in social interaction, communication, and sensory processing, and become visible through a wide variety of behavioral responses that differ from individuals without autism spectrum disorders. Despite significant research efforts, the exact causes of autism spectrum disorders remain poorly understood; however, researchers have gained extensive insights into possible pathomechanisms, even at the molecular level of cells. Many diagnostic criteria have been developed, adapted, and improved. The eight chapters in this book highlight the current state-of-the-art in many areas of autism spectrum disorders. Chapter 1 provides an overview of the epidemiology of autism spectrum disorders and the current knowledge of the underlying pathogenic mechanisms. Chapter 2 summarizes the diagnostic criteria and procedures and highlights present and upcoming therapeutic strategies. Chapter 3 reviews the adverse events and trauma in people with autism spectrum disorders. Chapters 4 and 5 focus on atypical sensory processing, and Chapter 6 discusses the genetic overlap of autism spectrum disorders with other neuropsychiatric disorders such as attention deficit hyperactivity disorder (ADHD), depression, and schizophrenia. Chapter 7 focuses on the contribution of abnormalities in mitochondria, and chapter 8 discusses gut-brain interactions and a potential role for microbiota in autism spectrum disorders. This book is aimed primarily at clinicians and scientists, but many areas will also be of interest to the layperson.

Autism Spectrum Disorders

2011-06-17
Autism Spectrum Disorders

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  • Author: David Amaral
  • Publisher: OUP USA
  • ISBN: 0195371828
  • Category : Medical
  • Languages : en
  • Pages : 1445

Information about the symptoms, treatment, and research on Autism spectrum disorders including Autism and Asperger syndrome.

Autism Spectrum Disorder

2021-06-09
Autism Spectrum Disorder

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  • Author: Michael Fitzgerald
  • Publisher: BoD – Books on Demand
  • ISBN: 1838810056
  • Category : Medical
  • Languages : en
  • Pages : 196

Autism spectrum disorder (ASD) is a complex condition that has extreme heterogeneity, which makes it extremely challenging from a diagnostic and etiological point of view. To add to the complexity, ASD typically has co-morbidity and overlap with other conditions outlined in this book, including epilepsy, attention-deficit/hyperactivity disorder (ADHD), and others. This book also examines monocyte cytokine profiles and catecholamines in ASD, genetic studies of autism, treatments, and controversial issues.

The Emerging Neuroscience of Autism Spectrum Disorders

2011
The Emerging Neuroscience of Autism Spectrum Disorders

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  • Author: Joseph Buxbaum
  • Publisher:
  • ISBN:
  • Category :
  • Languages : en
  • Pages : 0

Understanding Autism

2006-04-25
Understanding Autism

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  • Author: Steven O. Moldin
  • Publisher: CRC Press
  • ISBN: 1420004204
  • Category : Science
  • Languages : en
  • Pages : 552

Taking an all-inclusive look at the subject, Understanding Autism: From Basic Neuroscience to Treatment reviews state-of-the-art research on the diagnosis, treatment, and prevention of autism. The book addresses potential mechanisms that may underlie the development of autism and the neural systems that are likely to be affected by these molecular, genetic, and infectious etiologies. It reviews key findings that inform diagnosis, epidemiology, clinical neuroscience, and treatment. The book concludes with a discussion of the economic cost of autism and provides a biomedical and public health perspective of the impact of this devastating disease. With chapters authored by clinical and basic researchers at the forefront of molecular and systems neuroscience, clinical neuroscience, and health economics, the book presents a powerful and comprehensive synthesis of current research on autism and its underlying neural substrates. The book's two editors are considered elite pioneers in this area of research. Dr. Rubenstein was recently elected to the highly prestigious Institute of the Medicine, an honor reserved for those most committed to professional achievement and public service.