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This guide covers medical treatments and conditions-from heart disease to skin conditions-more common among children with Down syndrome.
Down syndrome (DS) is the most common example of neurogenetic aneuploid disorder leading to mental retardation. In most cases, DS results from an extra copy of chromosome 21 (HSA21) producing deregulated gene expression in brain that gives raise to subnormal intellectual functioning. The topic of this volume is of broad interest for the neuroscience community, because it tackles the concept of neurogenomics, that is, how the genome as a whole contributes to a neurodevelopmental cognitive disorders, such as DS, and thus to the development, structure and function of the nervous system. This volume of Progress in Brain Research discusses comparative genomics, gene expression atlases of the brain, network genetics, engineered mouse models and applications to human and mouse behavioral and cognitive phenotypes. It brings together scientists of diverse backgrounds, by facilitating the integration of research directed at different levels of biological organization, and by highlighting translational research and the application of the existing scientific knowledge to develop improved DS treatments and cures. Leading authors review the state-of-the-art in their field of investigation and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist
This book describes different medical problems that children with Down syndrome can encounter. Twelve chapters written by medical experts present information about the disease and give general guidelines for pediatric care. Readers are introduced to the epidemiology and risk factors associated with Down Syndrome followed by descriptions of medical issues related to the disease in children. These include neonatal problems, cardiac defects, respiratory disorders, gastrointestinal problems, nervous system disorders, dental disorders and more. The book also includes information on mental health development and social issues that arise in the lives of affected children. This handbook will be essential for medical students, healthcare professionals and special education personnel who are involved in the care of children with Down syndrome.
For nearly fifteen years Practical Decision Making in Health Care Ethics has offered scholars and students a highly accessible and teachable alternative to the dominant principle-based theories in the field. Devettere’s approach is not based on an ethics of abstract obligations and duties, but, following Aristotle, on how to live a fulfilled and happy life—in short, an ethics of personal well-being grounded in prudence, the virtue of ethical decision making. This third edition is revised and updated and includes discussions of several landmark cases, including the tragic stories of Terri Schiavo and Jesse Gelsinger (the first death caused by genetic research). Devettere addresses new topics such as partial-birth abortion law, embryonic stem cell research, infant euthanasia in The Netherlands, recent Vatican statements on feeding tubes, organ donation after cardiac death, new developments in artificial hearts, clinical trials developed by pharmaceutical companies to market new drugs, ghostwritten scientific articles published in major medical journals, and controversial HIV/AIDS research in Africa. This edition also includes a new chapter on the latest social and political issues in American health care. Devettere’s engaging text relies on commonsense moral concepts and avoids academic jargon. It includes a glossary of legal, medical, and ethical terms; an index of cases; and thoroughly updated bibliographic essays at the end of each chapter that offer resources for further reading. It is a true classic, brilliantly conceived and executed, and is now even more valuable to undergraduates and graduate students, medical students, health care professionals, hospital ethics committees and institutional review boards, and general readers interested in philosophy, medicine, and the rapidly changing field of health care ethics.
This reference provides contemporary information on all aspects of Down syndrome, investigating health concerns by age group and by organ system. The text sets out to identify and correct problems before they interrupt developing skills. It includes preventive medical checklists with summaries of appropriate medical intervention; supplies background information about history, genetics and epidemiology; outlines clinical management strategies; establishes guidelines on how to inform parents of the diagnosis and conveys practical suggestions on the handling and care of the infant; and offers a detailed review of the medical literature. Appendices provide information including growth charts and financial checklists.
Current Management in Child Neurology, Third Edition aims to provide busy practitioners with standard-of-care reviews on the evaluation and treatment of the most common complaints or conditions that relate to nervous system disorders and dysfunction. The book is designed to supplement standard textbooks that provide detailed information on etiology, pathogenesis, and therapeutic controversies in pediatric clinical neuroscience. This edition contains three sections and 98 chapters written by highly respected leaders in the field. It builds upon the success of previous editions by offering succinct updated reviews of the superb second edition chapters by 46 senior authors, 37 reviews by new authors, and 15 reviews by new authors on new topics. In the first section, Clinical Practice Trends, the reader will find data on the most common outpatient and inpatient conditions, insights into educational trends, pearls on conducting a meaningful neurologic examination, information on key Web sites, and advice on excelling at the art of medicine. In The Office Visit section, subheadings are organized according to the frequency of conditions in the office or clinic setting. The section offers management reviews in headache, seizures, epilepsy, neurobehavioral disorders, school readiness, developmental delay, and a range of other conditions. The final section, The Hospitalized Child, features 22 chapters addressing current therapy issues for trauma, meningitis and encephalitis, injury to the preterm and term brains, status epilepticus, and a host of other conditions associated with hospital care. Several chapters were added to this new edition, including selections on current pharmacotherapy for migraine, epilepsy, and ADHD, each with practitioner-friendly tables on drugs; one chapter was added on home management of breakthrough seizures. In addition, the Suggested Readings and Physician and Patient Resources sections of each chapter help trainees and caregivers do their homework about relevant conditions.
Quickly and confidently access the on-demand, go-to guidance you need to diagnose, treat, and manage hundreds of pediatric disorders! A new user-friendly "five-books-in-one" format makes it easier than ever for you to zero in on nearly 400 common pediatric diagnoses, common signs and symptoms (with diagnostic algorithms and differentials), plus commonly used tables, equations, and charts. Find the specific information you need quickly and easily with the aid of a consistent, bulleted outline format and alphabetical listings of diseases, topics, differential diagnoses, and algorithms. Deliver the best outcomes by incorporating clinical pearls from experts in the field into your practice. Reference the complete contents online anytime, fully searchable. Consult either the user-friendly text or the fully searchable web site to provide high-quality pediatric patient care - efficiently and effectively.
