The diagnosis and management of orofacial pain remains a challenge for most practicing Dentists. In this issue of Dental Clinics, guest editors Drs. David A Keith, Michael Schatman, Ronald J. Kulich, and Steven J. Scrivani bring their considerable expertise to Orofacial Pain Case Histories with Literature Reviews. The case-based teaching method has become popular in professional education and this subject lends itself to this approach as dentists can learn how to formulate a differential diagnosis, develop a treatment plan and follow patients' responses, thus providing information they can use on a daily basis. The literature review will allow the authors to expand on the case in a more traditional didactic style and cover the topic in a comprehensive manner. Top experts in the field cover key topics such as masticatory muscle pain; temporomandibular joint disc derangement: surgical treatment; temporomandibular joint arthropathy: nonsurgical management; fibromyalgia and temporomandibular disorders; burning mouth disorder; and more. Contains 16 relevant, practice-oriented topics including chronic facial pain; persistent idiopathic dentoalveolar pain disorder; post-traumatic trigeminal neuropathic pain disorder; trigeminal neuralgia; pathology mimicking orofacial pain; cancer pain; and more. Provides in-depth clinical reviews on orofacial pain case histories, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.