The COVID-19 pandemic has disrupted many global industries, none more so than healthcare, and has necessitated the need for health informatics innovations that can bridge time and space to provide timely care. It has also emphasized the need for a system-level informatics infrastructure to support the healthcare management of populations at a macro level, while also providing the necessary support for front line care delivery at a micro level. However, the need for change at a fast pace does not remove the need for an evidence base to support health technologies. This raises fundamental questions about how the informatics tools required can be delivered at pace without compromising the quality and safety of such tools. This book presents papers from the biennial conference on Context Sensitive Health Informatics, CSHI 2021, held as a virtual event on 15 and 16 November 2021. The theme of the 2021 conference was: The Role of Informatics in Global Pandemics, and this book includes 18 papers on a variety of topics, divided into 4 sections: health information management in the COVID-19 context; implementation of new practices and technologies in healthcare; sociotechnical analysis of task performance and workload in healthcare; and innovations in design and evaluation methods of health technologies. The book provides an overview of innovative health information systems rooted in robust scientific research on context and health information technology, and will be of interest to all those working in the field of health informatics.