Signal Transduction and the Coordination of B Lymphocyte Development and Function I

Signal Transduction and the Coordination of B Lymphocyte Development and Function I

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  • Author: Louis B. Justement
  • Publisher: Springer Science & Business Media
  • ISBN: 3642570666
  • Category : Medical
  • Languages : en
  • Pages : 279

Proper development and differentiation of B lymphocytes is es sential to ensure that an organism has the ability to mount an effective humoral immune response against foreign antigens. The immune system must maintain a balance between the deletion of harmful self-reactive B cells and the generation of a diverse rep ertoire of B cells that has the ability to recognize an almost un limited array of foreign antigens. The need to delete self-reactive cells is tempered by the need to avoid the generation of large functional holes in the repertoire of foreign antigen-specific B cells that patrol the periphery. To accomplish this, the immune system must reach a compromise by eliminating only the most dangerous autoreactive clones, while allowing less harmful au toreactive B cells to exist in the periphery where they may com plement the organism's ability to mount a rapid response against invading micro-organisms. Those autoreactive cells that do enter the peripheral pool are subject to a number of conditional re straints that effectively attenuate their ability to respond to self antigens. Deleterious alterations in the homeostasis between tolerance induction and recruitment of B cells into the functional repertoire may lead to increased susceptibility to autoimmune disease or infection, respectively. Therefore, delineation of the molecular processes that maintain immunological homeostasis in the B cell compartment is critical.


Signaling in the Heart

Signaling in the Heart

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  • Author: José Marín-García
  • Publisher: Springer Science & Business Media
  • ISBN: 1441994610
  • Category : Medical
  • Languages : en
  • Pages : 511

Signal transduction pathways are at the core of most biological processes and are critical regulators of heart physiology and pathophysiology. The heart is both a transmitter and dynamic receptor of a variety of intracellular and extracellular stimuli, playing a critical role of an integrator of diverse signaling mechanisms. Alterations in signaling pathways are contributing factors in the development and progression of a broad spectrum of diseases, ranging from dysrhythmias and atherosclerosis to hypertension and the metabolic syndrome. Targeting specific components of these signaling pathways has been shown to be effective in preclinical studies with significant therapeutic impact. This book brings together current knowledge in cardiovascular cell signal transduction mechanisms, advances in novel therapeutic approaches to improve cardiac function, and discussion of future directions. Presented from a post-genomic perspective, this exciting book introduces important new ideas in cardiovascular systems biology. It is an invaluable reference for cardiology researchers and practitioners.


Interjurisdictional Coordination of Katella Avenue Traffic Signals

Interjurisdictional Coordination of Katella Avenue Traffic Signals

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  • Author: Wilfred W. Recker
  • Publisher:
  • ISBN:
  • Category : Electronic traffic controls
  • Languages : en
  • Pages : 160


Coordination of Traffic Signals in Networks and Related Graph Theoretical Problems on Spanning Trees

Coordination of Traffic Signals in Networks and Related Graph Theoretical Problems on Spanning Trees

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  • Author: Gregor Wünsch
  • Publisher: Cuvillier Verlag
  • ISBN: 3736925794
  • Category : Mathematics
  • Languages : en
  • Pages : 154


RSC, Railway Signaling and Communications

RSC, Railway Signaling and Communications

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  • Author:
  • Publisher:
  • ISBN:
  • Category : Railroads
  • Languages : en
  • Pages : 520


Coordination of Plant Endomembrane System with Developmental Signals and Environmental Stimuli.

Coordination of Plant Endomembrane System with Developmental Signals and Environmental Stimuli.

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  • Author: Ruixi Li
  • Publisher: Frontiers Media SA
  • ISBN: 2889769372
  • Category : Science
  • Languages : en
  • Pages : 98


LTE-Advanced

LTE-Advanced

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  • Author: Sassan Ahmadi
  • Publisher: Academic Press
  • ISBN: 0124051782
  • Category : Technology & Engineering
  • Languages : en
  • Pages : 1152

This book is an in-depth, systematic and structured technical reference on 3GPP's LTE-Advanced (Releases 10 and 11), covering theory, technology and implementation, written by an author who has been involved in the inception and development of these technologies for over 20 years. The book not only describes the operation of individual components, but also shows how they fit into the overall system and operate from a systems perspective. Uniquely, this book gives in-depth information on upper protocol layers, implementation and deployment issues, and services, making it suitable for engineers who are implementing the technology into future products and services. Reflecting the author's 25 plus years of experience in signal processing and communication system design, this book is ideal for professional engineers, researchers, and graduate students working in cellular communication systems, radio air-interface technologies, cellular communications protocols, advanced radio access technologies for beyond 4G systems, and broadband cellular standards. An end-to-end description of LTE/LTE-Advanced technologies using a top-down systems approach, providing an in-depth understanding of how the overall system works Detailed algorithmic descriptions of the individual components’ operation and inter-connection Strong emphasis on implementation and deployment scenarios, making this a very practical book An in-depth coverage of theoretical and practical aspects of LTE Releases 10 and 11 Clear and concise descriptions of the underlying principles and theoretical concepts to provide a better understanding of the operation of the system’s components Covers all essential system functionalities, features, and their inter-connections based on a clear protocol structure, including detailed signal flow graphs and block diagrams Includes methodologies and results related to link-level and system-level evaluations of LTE-Advanced Provides understanding and insight into the advanced underlying technologies in LTE-Advanced up to and including Release 11: multi-antenna signal processing, OFDM, carrier aggregation, coordinated multi-point transmission and reception, eICIC, multi-radio coexistence, E-MBMS, positioning methods, real-time and non-real-time wireless multimedia applications


Encyclopedia of Transportation

Encyclopedia of Transportation

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  • Author: Mark Garrett
  • Publisher: SAGE Publications
  • ISBN: 148334651X
  • Category : Social Science
  • Languages : en
  • Pages : 2000

Viewing transportation through the lens of current social, economic, and policy aspects, this four-volume reference work explores the topic of transportation across multiple disciplines within the social sciences and related areas, including geography, public policy, business, and economics. The book’s articles, all written by experts in the field, seek to answer such questions as: What has been the legacy, not just economically but politically and socially as well, of President Eisenhower’s modern interstate highway system in America? With that system and the infrastructure that supports it now in a state of decline and decay, what’s the best path for the future at a time of enormous fiscal constraints? Should California politicians plunge ahead with plans for a high-speed rail that every expert says—despite the allure—will go largely unused and will never pay back the massive investment while at this very moment potholes go unfilled all across the state? What path is best for emerging countries to keep pace with dramatic economic growth for their part? What are the social and financial costs of gridlock in our cities? Features: Approximately 675 signed articles authored by prominent scholars are arranged in A-to-Z fashion and conclude with Further Readings and cross references. A Chronology helps readers put individual events into historical context; a Reader’s Guide organizes entries by broad topical or thematic areas; a detailed index helps users quickly locate entries of most immediate interest; and a Resource Guide provides a list of journals, books, and associations and their websites. While articles were written to avoid jargon as much as possible, a Glossary provides quick definitions of technical terms. To ensure full, well-rounded coverage of the field, the General Editor with expertise in urban planning, public policy, and the environment worked alongside a Consulting Editor with a background in Civil Engineering. The index, Reader’s Guide, and cross references combine for thorough search-and-browse capabilities in the electronic edition. Available in both print and electronic formats, Encyclopedia of Transportation is an ideal reference for libraries and those who want to explore the issues that surround transportation in the United States and around the world.


3D Imaging Technologies—Multidimensional Signal Processing and Deep Learning

3D Imaging Technologies—Multidimensional Signal Processing and Deep Learning

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  • Author: Lakhmi C. Jain
  • Publisher: Springer Nature
  • ISBN: 9811631808
  • Category : Technology & Engineering
  • Languages : en
  • Pages : 332

This book presents high-quality research in the field of 3D imaging technology. The second edition of International Conference on 3D Imaging Technology (3DDIT-MSP&DL) continues the good traditions already established by the first 3DIT conference (IC3DIT2019) to provide a wide scientific forum for researchers, academia and practitioners to exchange newest ideas and recent achievements in all aspects of image processing and analysis, together with their contemporary applications. The conference proceedings are published in 2 volumes. The main topics of the papers comprise famous trends as: 3D image representation, 3D image technology, 3D images and graphics, and computing and 3D information technology. In these proceedings, special attention is paid at the 3D tensor image representation, the 3D content generation technologies, big data analysis, and also deep learning, artificial intelligence, the 3D image analysis and video understanding, the 3D virtual and augmented reality, and many related areas. The first volume contains papers in 3D image processing, transforms and technologies. The second volume is about computing and information technologies, computer images and graphics and related applications. The two volumes of the book cover a wide area of the aspects of the contemporary multidimensional imaging and the related future trends from data acquisition to real-world applications based on various techniques and theoretical approaches.


Academic Press Library in Signal Processing

Academic Press Library in Signal Processing

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  • Author:
  • Publisher: Academic Press
  • ISBN: 0123972248
  • Category : Technology & Engineering
  • Languages : en
  • Pages : 1350

This second volume, edited and authored by world leading experts, gives a review of the principles, methods and techniques of important and emerging research topics and technologies in communications and radar engineering. With this reference source you will: Quickly grasp a new area of research Understand the underlying principles of a topic and its application Ascertain how a topic relates to other areas and learn of the research issues yet to be resolved Quick tutorial reviews of important and emerging topics of research in array and statistical signal processing Presents core principles and shows their application Reference content on core principles, technologies, algorithms and applications Comprehensive references to journal articles and other literature on which to build further, more specific and detailed knowledge Edited by leading people in the field who, through their reputation, have been able to commission experts to write on a particular topic