Coalescent

2004-11-23
Coalescent

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  • Author: Stephen Baxter
  • Publisher: Del Rey
  • ISBN: 0345457862
  • Category : Fiction
  • Languages : en
  • Pages : 546

“Lean, taut storytelling . . . breakneck stuff . . . Arguably his most accessible book to date—Baxter [is] resplendent.”—SFX magazine When his father dies suddenly, George Poole stumbles onto a family secret: He has a twin sister he never knew existed, who was raised by an enigmatic cult called the Order. The Order is a hive—a human hive with a dominant queen—that has prospered below the streets of Rome for almost two millennia. After Poole enters the Order’s vast underground city and meets the disturbing inhabitants, he uncovers evidence that they have embarked on a divergent evolutionary path. These genetically superior humans are equipped with the tools necessary to render modern Homo sapiens as extinct as the Neanderthals. And now they are preparing to leave their underground realm. “[Excels] at both action-packed storytelling and philosophical speculation.”—Library Journal “Utterly fascinating . . . constantly surprising . . . Coalescent reveals a new side to Baxter’s vast talent.”—Locus

Coalescent Theory

2016-04-22
Coalescent Theory

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  • Author: John Wakely
  • Publisher: Roberts
  • ISBN: 9780974707754
  • Category : Science
  • Languages : en
  • Pages : 0

This textbook provides the foundation for molecular population genetics and genomics. It shows the conceptual framework for studies of DNA sequence variation within species, and is the source of essential tools for making inferences about mutation, recombination, population structure and natural selection from DNA sequence data.

Gene Genealogies, Variation and Evolution: A primer in coalescent theory

2004-12-09
Gene Genealogies, Variation and Evolution: A primer in coalescent theory

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  • Author: Jotun Hein
  • Publisher: Oxford University Press, USA
  • ISBN: 9780191546150
  • Category : Population genetics
  • Languages : en
  • Pages : 298

Authored by leading experts, this seminal text presents a straightforward and elementary account of coalescent theory, which is a central concept in the study of genetic sequence variation observed in a population. Rich in examples and illustrations it is ideal for a graduate course in statistics, population, molecular and medical genetics, bioscience and medicine, and for students studying the evolution of human population and disease. It is also an invaluable reference for bioscientists and statisticians in the pharmaceutical industry and academia - ;Coalescent theory is a central concept in the study of genetic sequence variation that probabilistically describes the genealogy relating the sampled sequences. In this text, besides fulfilling the glaring need for such a book, the authors present this theory in a straightforward and elementary manner and describe the statistical and computational methods used in modelling and analyzing genetic sequence variation. Rich in examples and illustrations the book covers basic concepts, complications arising from geographical structure and recombination before considering aspects of statistical inference based on these models. The book ends with chapters on Gene Mapping, which combines sequence variation data with phenotypic data (such as disease) to define areas of the genome where genes are responsible for the trait, and Human Evolution, a research area that is experiencing a renaissance due to the enormous amounts of data produced in molecular studies. Authored by leading experts, this seminal text presents a straightforward and elementary account of coalescent theory, which is a central concept in the study of genetic sequence variation observed in a population. It is highly suitable for a graduate course in statistics, population, molecular and medical genetics, bioscience and medicine and students studying the evolution of human population and disease, and will be an invaluable reference for bioscientists and statisticians in the pharmaceutical industry and academia - ;an excellent and timely book that should appeal to a variety of people in genetics and applied mathematics. - Professor Montgomery Slatkin (Berkeley);the authors are outstanding experts in the field, and the book is topical and timely. - Professor David Balding (Imperial College);Hein, Schierup and Wiuf have written the first general book on the coalescent. It is an engaging combination of clear mathematical derivation and real data examples. - Professor Joe Felsenstein (University of Washington)

Coalescent Argumentation

2013-11-05
Coalescent Argumentation

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  • Author: Michael A. Gilbert
  • Publisher: Routledge
  • ISBN: 1136685243
  • Category : Language Arts & Disciplines
  • Languages : en
  • Pages : 176

Coalescent Argumentation is based on the concept that arguments can function from agreement, rather than disagreement. To prove this idea, Gilbert first discusses how several components--emotional, visceral (physical) and kisceral (intuitive) are utilized in an argumentative setting by people everyday. These components, also characterized as "modes," are vital to argumentative communication because they affect both the argument and the resulting outcome. In addition to the components/modes, this book also stresses the goals in argumentation as a means for understanding one's own and one's opposer's positions. Gilbert argues that by viewing positions as complex human events involving a variety of communicative modes, we are better able to find commonalities across positions, and, therefore, move from conflict to resolution. By focusing on agreement and shared goals in all modes, arguers can coalesce diverse positions and more easily distinguish between minor or unrelated differences and core disagreements. This permits much greater latitude for locating shared beliefs, values, and attitudes that will lead to conflict resolution.

Handbook of Statistical Genomics

2019-07-09
Handbook of Statistical Genomics

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  • Author: David J. Balding
  • Publisher: John Wiley & Sons
  • ISBN: 1119429250
  • Category : Science
  • Languages : en
  • Pages : 1828

A timely update of a highly popular handbook on statistical genomics This new, two-volume edition of a classic text provides a thorough introduction to statistical genomics, a vital resource for advanced graduate students, early-career researchers and new entrants to the field. It introduces new and updated information on developments that have occurred since the 3rd edition. Widely regarded as the reference work in the field, it features new chapters focusing on statistical aspects of data generated by new sequencing technologies, including sequence-based functional assays. It expands on previous coverage of the many processes between genotype and phenotype, including gene expression and epigenetics, as well as metabolomics. It also examines population genetics and evolutionary models and inference, with new chapters on the multi-species coalescent, admixture and ancient DNA, as well as genetic association studies including causal analyses and variant interpretation. The Handbook of Statistical Genomics focuses on explaining the main ideas, analysis methods and algorithms, citing key recent and historic literature for further details and references. It also includes a glossary of terms, acronyms and abbreviations, and features extensive cross-referencing between chapters, tying the different areas together. With heavy use of up-to-date examples and references to web-based resources, this continues to be a must-have reference in a vital area of research. Provides much-needed, timely coverage of new developments in this expanding area of study Numerous, brand new chapters, for example covering bacterial genomics, microbiome and metagenomics Detailed coverage of application areas, with chapters on plant breeding, conservation and forensic genetics Extensive coverage of human genetic epidemiology, including ethical aspects Edited by one of the leading experts in the field along with rising stars as his co-editors Chapter authors are world-renowned experts in the field, and newly emerging leaders. The Handbook of Statistical Genomics is an excellent introductory text for advanced graduate students and early-career researchers involved in statistical genetics.

Combinatorial Stochastic Processes

2006-05-11
Combinatorial Stochastic Processes

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  • Author: Jim Pitman
  • Publisher: Springer Science & Business Media
  • ISBN: 354030990X
  • Category : Mathematics
  • Languages : en
  • Pages : 257

The purpose of this text is to bring graduate students specializing in probability theory to current research topics at the interface of combinatorics and stochastic processes. There is particular focus on the theory of random combinatorial structures such as partitions, permutations, trees, forests, and mappings, and connections between the asymptotic theory of enumeration of such structures and the theory of stochastic processes like Brownian motion and Poisson processes.

Population Genetics

2021-02-10
Population Genetics

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  • Author: Matthew B. Hamilton
  • Publisher: John Wiley & Sons
  • ISBN: 111843689X
  • Category : Science
  • Languages : en
  • Pages : 501

Now updated for its second edition, Population Genetics is the classic, accessible introduction to the concepts of population genetics. Combining traditional conceptual approaches with classical hypotheses and debates, the book equips students to understand a wide array of empirical studies that are based on the first principles of population genetics. Featuring a highly accessible introduction to coalescent theory, as well as covering the major conceptual advances in population genetics of the last two decades, the second edition now also includes end of chapter problem sets and revised coverage of recombination in the coalescent model, metapopulation extinction and recolonization, and the fixation index.

Theories of Population Variation in Genes and Genomes

2014-11-23
Theories of Population Variation in Genes and Genomes

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  • Author: Freddy Bugge Christiansen
  • Publisher: Princeton University Press
  • ISBN: 0691165890
  • Category : Science
  • Languages : en
  • Pages : 431

This textbook provides an authoritative introduction to both classical and coalescent approaches to population genetics. Written for graduate students and advanced undergraduates by one of the world's leading authorities in the field, the book focuses on the theoretical background of population genetics, while emphasizing the close interplay between theory and empiricism. Traditional topics such as genetic and phenotypic variation, mutation, migration, and linkage are covered and advanced by contemporary coalescent theory, which describes the genealogy of genes in a population, ultimately connecting them to a single common ancestor. Effects of selection, particularly genomic effects, are discussed with reference to molecular genetic variation. The book is designed for students of population genetics, bioinformatics, evolutionary biology, molecular evolution, and theoretical biology--as well as biologists, molecular biologists, breeders, biomathematicians, and biostatisticians. Contains up-to-date treatment of key areas in classical and modern theoretical population genetics Provides in-depth coverage of coalescent theory Discusses genomic effects of selection Gives examples from empirical population genetics Incorporates figures, diagrams, and boxed features throughout Includes end-of-chapter exercises Speaks to a wide range of students in biology, bioinformatics, and biostatistics

Glasscock-Shambaugh Surgery of the Ear

2010
Glasscock-Shambaugh Surgery of the Ear

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  • Author: Lloyd B. Minor
  • Publisher: PMPH-USA
  • ISBN: 9781607950264
  • Category : Ear
  • Languages : en
  • Pages : 828

Updated with new color graphics and new video CD of surgical and diagnostic procedures, this 6th edition retains its heritage as the classic textbook in otology and neurotology. Coverage includes scientific foundations and fundamentals, clinical evaluation and rehabilitation and sections on the external ear, inner ear, tympanomastoid compartment, internal auditory canal/Cerebellopontine angle/petrous apex and skull-based surgery. This edition integrates all the latest research in genetics, biotechnical advancements in laser and image-guided systems and clinical innovations and techniques of the past 7 years. Woven throughout is an intriguing historical overview of those who pioneered the early surgical interventions from 1950 to the present and the influences on current clinical practice. Editors of this edition, Julianna Gulya, Lloyd Minor and Dennis Poe are internationally renowned figures in the field of otology/neurotology. This 6th edition enormously benefits from their editorial direction and wealth of knowledge and clinical expertise. SOTE 6 remains the classic text and reference of choice for otolaryngologists and neurosurgeons and an essential addition to the libraries of experienced surgeons, trainees, or those preparing for board exams. New Chapters written by well-recognized leaders that include the latest research and clinical studies include: Tumor Biology Stereotactic Radiosurgery and Radiotherapy Ossicular Reconstruction Management of Cerebrospinal Fluid Leaks Surgical Treatment of Peripheral Vestibular Disorders Hearing Aids Tinnitus Rehabilitation Vestibular Rehabilitation Updated Temporal Bone Dissection Guide

Progress in Mathematical Ecology

2018-12-07
Progress in Mathematical Ecology

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  • Author: Sergei Petrovskii
  • Publisher: MDPI
  • ISBN: 3038973122
  • Category : Electronic books
  • Languages : en
  • Pages : 215

This book is a printed edition of the Special Issue "Progress in Mathematical Ecology" that was published in Mathematics